Projects per year
Personal profile
Chinese Name
張嘉龍
Biography
Dr Allen Cheung's PhD work involved identifying a unique subset of viral genes expressed by human cytomegalovirus latent infection of CD34+ hematopoietic myeloid progenitor cells using viral custom-made microarrays. One of these genes (UL111A/viral homolog of humanIL-10) downregulates MHC class II molecules to prevent T cell recognition; these work resulted in two publications in Blood.
In his postdoc in Tokyo, he was involved in delineating the mechanism by which T cells produce IFN-γ following IL-12/STAT4 stimulation. During his time in HKU, he was involved in solving the underlying mechanism of two novel vaccines (J Clin Invest and Mol Therapy), as well as the interplay between CMV and HIV co-infection in CD34+ stem cells (Blood Advances). Moreover, I identified and characterised a novel PD-1 isoform (Delta42PD1) and found its cognate receptor to be TLR4, which underlie gut inflammation during acute HIV-1 infection (Nature Microbiology).
Research Interests
- Novel immunological protein Δ42PD1 and its role in inflammatory diseases
- Human cytomegalovirus (HCMV) latent infection in CD34+ stem cells and associated diseases
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Ka Loon Allen CHEUNG is active. Topic labels come from the works of this scholar.
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Translating Disease-Mechanism Discoveries to Improve Treatment of Biliary Atresia, an Intractable Newborn Liver Disease
1/01/22 → 31/12/26
Project: Research project
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Viral Inhibition of Pseudo-SARS-CoV-2 Using a UV-C Equipped Ventilation Pipe
16/03/21 → 15/06/21
Project: Research project
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Defining human cytomegalovirus latent genes in favor of human immunodeficiency virus type 1 coinfection in CD34+ cells and association in HIV patients
1/10/19 → 30/09/22
Project: Research project
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Characterising the role of a novel PD1 isoform expressed on gamma-delta T cells in HIV-1 infection
1/06/16 → 30/09/18
Project: Research project
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Association of human cytomegalovirus in urine with end-organ diseases in stage 2/3 HIV-1-infected individuals
Zhao, F., Fung, T. Y., Chen, Z., Wang, H. & Cheung, A. K. L., Jan 2023, In: Journal of Clinical Virology. 158, 105351.Research output: Contribution to journal › Article › peer-review
Open Access -
Characteristics of CD8+ Stem Cell-Like Memory T Cell Subset in Chronic Hepatitis C Virus Infection
Lu, X., Song, B., Weng, W., Su, B., Wu, H., Cheung, A. K. L., Zhang, T. & Gao, Y., 16 Jan 2023, In: Viral Immunology. 36, 1, p. 25-32 8 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Consistent neutralization of circulating omicron sub-variants by hybrid immunity up to 6 months after booster vaccination
Cheung, A. K. L., Lu, Y., Zhu, Y., Fung, T. Y., Zheng, Y., Zheng, Z. & Hong, P., Apr 2023, In: Journal of Medical Virology. 95, 4, e28694.Research output: Contribution to journal › Article › peer-review
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EBV latent membrane protein 1 augments γδ T cell cytotoxicity against nasopharyngeal carcinoma by induction of butyrophilin molecules
Liu, Y., Lui, K. S., Ye, Z., Fung, T. Y., Chen, L., Sit, P. Y., Leung, C. Y., Mak, N. K., Wong, K. L., Lung, H. L., Tanaka, Y. & Cheung, A. K. L., Jan 2023, In: Theranostics. 13, 2, p. 458-471 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Abnormal Shift in B Memory Cell Profile Is Associated With the Expansion of Circulating T Follicular Helper Cells via ICOS Signaling During Acute HIV-1 Infection
Lu, X., Zhang, X., Cheung, A. K. L., Moog, C., Xia, H., Li, Z., Wang, R., Ji, Y., Xia, W., Liu, Z., Yuan, L., Wang, X., Wu, H., Zhang, T. & Su, B., 10 Feb 2022, In: Frontiers in Immunology. 13, 12 p., 837921.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus)