20062022

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Personal profile

Chinese Name

張嘉龍

Biography

Dr Allen Cheung's PhD work involved identifying a unique subset of viral genes expressed by human cytomegalovirus latent infection of CD34+ hematopoietic myeloid progenitor cells using viral custom-made microarrays. One of these genes (UL111A/viral homolog of humanIL-10) downregulates MHC class II molecules to prevent T cell recognition; these work resulted in two publications in Blood.

 

In his postdoc in Tokyo, he was involved in delineating the mechanism by which T cells produce IFN-γ following IL-12/STAT4 stimulation. During his time in HKU, he was involved in solving the underlying mechanism of two novel vaccines (J Clin Invest and Mol Therapy), as well as the interplay between CMV and HIV co-infection in CD34+ stem cells (Blood Advances). Moreover, I identified and characterised a novel PD-1 isoform (Delta42PD1) and found its cognate receptor to be TLR4, which underlie gut inflammation during acute HIV-1 infection (Nature Microbiology).

Research Interests

  • Novel immunological protein Δ42PD1 and its role in inflammatory diseases
  • Human cytomegalovirus (HCMV) latent infection in CD34+ stem cells and associated diseases

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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Dive into the research topics where Ka Loon Allen CHEUNG is active. Topic labels come from the works of this scholar.
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