Projects per year
Personal profile
Chinese Name
張嘉龍
Biography
Dr Allen Cheung's PhD work involved identifying a unique subset of viral genes expressed by human cytomegalovirus latent infection of CD34+ hematopoietic myeloid progenitor cells using viral custom-made microarrays. One of these genes (UL111A/viral homolog of humanIL-10) downregulates MHC class II molecules to prevent T cell recognition; these work resulted in two publications in Blood.
In his postdoc in Tokyo, he was involved in delineating the mechanism by which T cells produce IFN-γ following IL-12/STAT4 stimulation. During his time in HKU, he was involved in solving the underlying mechanism of two novel vaccines (J Clin Invest and Mol Therapy), as well as the interplay between CMV and HIV co-infection in CD34+ stem cells (Blood Advances). Moreover, I identified and characterised a novel PD-1 isoform (Delta42PD1) and found its cognate receptor to be TLR4, which underlie gut inflammation during acute HIV-1 infection (Nature Microbiology).
Research Interests
- Novel immunological protein Δ42PD1 and its role in inflammatory diseases
- Human cytomegalovirus (HCMV) latent infection in CD34+ stem cells and associated diseases
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Dive into the research topics where Ka Loon Allen CHEUNG is active. Topic labels come from the works of this scholar.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Equipment Matching Fund - Desktop Scanning Electron Microscope (Desktop SEM)
QIU, J. (PI), CHIU, M. Y. (CoI), CHEUNG, K. L. A. (CoI), ZHAO, Z. (CoI), LIAO, P. (CoI) & ZHAO, J. (CoI)
26/03/24 → 25/03/26
Project: Research project
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Translating Disease-Mechanism Discoveries to Improve Treatment of Biliary Atresia, an Intractable Newborn Liver Disease
Lui, V. C. (PI), CHEUNG, K. L. A. (CoPI), Tam, P. K. H. (CoPI), De Coppi , P. (CoPI), Lendahl , U. (CoPI), Sampaziotis , F. (CoPI), Sham, P. C. (CoPI), Wong, I. C. K. (CoPI), Wong, K. K. Y. (CoPI), Yip , K. Y. L. (CoPI), Cheah, K. S. E. (CoPI), Chung, B. H. Y. (CoPI), Chung, P. H. Y. (CoPI), Li , L. (CoPI), O'Callaghan , C. (CoPI), Rowitch , D. (CoPI), Tang , C. S. M. (CoPI), Bin , W. (CoPI), Davenport, M. (CoPI), Jenkins , D. (CoPI), Mitchison , H. (CoPI), Elvassore , N. (CoPI), Vallier , L. (CoPI) & Zhang, M. (CoPI)
1/01/22 → 31/12/26
Project: Research project
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Gamma-delta T cells as immunotherapy against mesothelioma
CHEUNG, K. L. A. (PI)
1/05/21 → 3/07/24
Project: Research project
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Viral Inhibition of Pseudo-SARS-CoV-2 Using a UV-C Equipped Ventilation Pipe
CHEUNG, K. L. A. (PI)
16/03/21 → 15/06/21
Project: Research project
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Defining human cytomegalovirus latent genes in favor of human immunodeficiency virus type 1 coinfection in CD34+ cells and association in HIV patients
CHEUNG, K. L. A. (PI)
1/10/19 → 30/09/22
Project: Research project
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Extracellular Silica Nanomatrices Promote In Vitro Maturation of Anti-tumor Dendritic Cells via Activation of Focal Adhesion Kinase
Tam, S. W., Cheung, K. L. A., Qin, P., Zhang, S., Huang, Z. & Yung, K. L., 13 Sept 2024, (E-pub ahead of print) In: Advanced Materials. 16 p.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Anti-PD1 does not improve pyroptosis induced by γδ T cells but promotes tumor regression in a pleural mesothelioma mouse model
Lui, K. S., Ye, Z., Chan, H. C., Tanaka, Y. & Cheung, A. K. L., 23 Nov 2023, In: Frontiers in Immunology. 14, 11 p., 1282710.Research output: Contribution to journal › Journal article › peer-review
Open Access2 Citations (Scopus) -
Association of human cytomegalovirus in urine with end-organ diseases in stage 2/3 HIV-1-infected individuals
Zhao, F., Fung, T. Y., Chen, Z., Wang, H. & Cheung, A. K. L., Jan 2023, In: Journal of Clinical Virology. 158, 105351.Research output: Contribution to journal › Journal article › peer-review
Open Access1 Citation (Scopus) -
Characteristics of CD8+ Stem Cell-Like Memory T Cell Subset in Chronic Hepatitis C Virus Infection
Lu, X., Song, B., Weng, W., Su, B., Wu, H., Cheung, A. K. L., Zhang, T. & Gao, Y., 16 Jan 2023, In: Viral Immunology. 36, 1, p. 25-32 8 p.Research output: Contribution to journal › Journal article › peer-review
2 Citations (Scopus) -
Consistent neutralization of circulating omicron sub-variants by hybrid immunity up to 6 months after booster vaccination
Cheung, A. K. L., Lu, Y., Zhu, Y., Fung, T. Y., Zheng, Y., Zheng, Z. & Hong, P., Apr 2023, In: Journal of Medical Virology. 95, 4, e28694.Research output: Contribution to journal › Journal article › peer-review
1 Citation (Scopus)