Aiping LYU

2020

ISO中医药国际标准理论研究与实践

Translated title of the contribution: ISO Standards for Traditional Chinese Medicine: Theory and Practice沈远东 (ed.), 桑珍 (ed.) & 吕爱平 (ed.), Dec 2020, 上海科学技术出版社. 341 p.

Research output: Book/Report › Book or report › peer-review

Low Level Antibodies Against Alpha-Tropomyosin Are Associated With Increased Risk of Coronary Heart Disease

Zhang, Y., Zhao, H., Liu, B., Li, L., Zhang, L., Bao, M., Ji, X., He, X., Yi, J., Chen, P., Lu, C. & Lu, A., 27 Feb 2020, In: Frontiers in Pharmacology. 11, 195.

Research output: Contribution to journal › Journal article › peer-review

Open Access

10 Citations (Scopus)

Miliusol Suppress Immune Evasion of Colorectal Cancer Through Inhibiting Autophagy

Du, Y., Xia, Y., Lyu, A. & Zhang, H., 14 Aug 2020, The 16th International Postgraduates Symposium on Chiense Medicines (IPSCM) Programme Book = 第十六屆國際研究生中醫藥研討會會議手冊. Hong Kong, p. 86-87 2 p.

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

Natural ingredient-based polymeric nanoparticles for cancer treatment

Wong, K. H., Lu, A., Chen, X. & Yang, Z., 2 Aug 2020, In: Molecules. 25, 16, 3620.

Research output: Contribution to journal › Review article › peer-review

Open Access

69 Citations (Scopus)

Naturally Occurring TPE-CA Maintains Gut Microbiota and Bile Acids Homeostasis via FXR Signaling Modulation of the Liver–Gut Axis

Liu, L., Liu, Z., Li, H., Cao, Z., Li, W., Song, Z., Li, X., Lu, A., Lu, C. & Liu, Y., Feb 2020, In: Frontiers in Pharmacology. 11, 12.

Research output: Contribution to journal › Journal article › peer-review

Open Access

43 Citations (Scopus)

pH-Responsive Fluorescence Enhanced Nanogel for Targeted Delivery of AUR and CDDP Against Breast Cancer

Cao, Z., Li, W., Liu, R., Li, C., Song, Y., Liu, G., Chen, Y., Lu, C., Lyu, A. & Liu, Y., 29 Oct 2020, In: International Journal of Nanomedicine. 2020, 15, p. 8369-8382 14 p.

Research output: Contribution to journal › Journal article › peer-review

Open Access

8 Citations (Scopus)

Pien Tze Huang alleviate the joint inflammation in collagen-induced arthritis mice

Deng, Y. Q., Luo, H., Shu, J., Shu, H., Lu, C., Zhao, N., Geng, Y., He, X. & Lu, A., 30 Mar 2020, In: Chinese Medicine. 15, 1, 9 p., 30.

Research output: Contribution to journal › Journal article › peer-review

Open Access

22 Citations (Scopus)

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

Kang, W., Fan, Y., Du, Y., Tonkova, E. A., Hsu, Y-H., Tan, K. V., Alexander, S., Wong, B. S., Yang, H., LUO, J., Yao, K., Yang, J., Hu, X., Liu, T., Gan, Y., Zhang, J., Zhao, J. J., Konstantopoulos, K., Friedl, P., Khong, P. L., & 5 othersLu, A., Hung, M-C., Brenner, M. B., Segall, J. E. & Gu, Z., 27 Aug 2020, Cold Spring Harbor Laboratory Press, 34 p. (bioRxiv).

Research output: Working paper › Preprint

Open Access

Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis

Shi, Y., Shu, H., Wang, X., Zhao, H., Lu, C., Lu, A. & He, X., 7 Oct 2020, In: Frontiers in Pharmacology. 11, 16 p., 561962.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Citations (Scopus)

PRISMA (Preferred reporting items for systematic reviews and meta-analyses) extension for Chinese herbal medicines 2020 (PRISMA-CHM 2020)

Zhang, X., Tian, R., Lam, W. C., Yao, L., Wang, X., Cheng, C. W., Liu, F., Chan, J. C. P., Aixinjueluo, Q., Lau, C. T., Chen, Y., Yang, K., Wu, T., Lyu, A. & Bian, Z., 9 Sept 2020, In: The American Journal of Chinese Medicine. 48, 6, p. 1279-1313 35 p.

Research output: Contribution to journal › Journal article › peer-review

Open Access

64 Citations (Scopus)

PRISMA extension for moxibustion 2020: recommendations, explanation, and elaboration

Zhang, X., Tian, R., Lam, W. C., Cheng, C. W., Yao, L., Wang, X. Q., Li, S. Y., Aixinjueluo, Q. Y., Yang, K. H., Shang, H. C., Wu, T. X., Lyu, A. & Bian, Z., 25 Oct 2020, In: Systematic Reviews. 9, 1, 11 p., 247.

Research output: Contribution to journal › Journal article › peer-review

Open Access

11 Citations (Scopus)

Progress in 11β-HSD1 inhibitors for the treatment of metabolic diseases: A comprehensive guide to their chemical structure diversity in drug development

Chuanxin, Z., Shengzheng, W., Lei, D., Duoli, X., Jin, L., Fuzeng, R., Lu, A. & Zhang, G., 1 Apr 2020, In: European Journal of Medicinal Chemistry. 191, 20 p., 112134.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

18 Citations (Scopus)

91 Downloads (Pure)

RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies

Wu, X., Li, F., Dang, L., Liang, C., Lu, A. & Zhang, G., 11 Feb 2020, In: Frontiers in Cell and Developmental Biology. 8, 14 p., 76.

Research output: Contribution to journal › Journal article › peer-review

Open Access

65 Citations (Scopus)

Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells

Gong, M., Ye, S., Li, W. X., Zhang, J., Liu, Y., Zhu, J., Lv, W., Zhang, H., Wang, J., LYU, A. & He, K., 1 Jun 2020, In: American Journal of Physiology - Cell Physiology. 318, 6, p. C1123-C1135 13 p.

Research output: Contribution to journal › Journal article › peer-review

Open Access

7 Citations (Scopus)

Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis

Zhao, H., Lu, A. & He, X., 19 Nov 2020, In: Frontiers in Cell and Developmental Biology. 8, 9 p., 600867.

Research output: Contribution to journal › Review article › peer-review

Open Access

19 Citations (Scopus)

Sclerostin loop3: a potential target for developing a next generation sclerostin inhibitor for bone anabolic therapy with low cardiovascular concern (Abstract)

Yu, Y., Wang, L., Ni, S., Zhuo, Z., Chu, H. Y., Zhang, N., Li, D., Liu, J., Lyu, A., Zhang, B. T. & Zhang, G., Nov 2020, In: Journal of Bone and Mineral Research. 35, S1, p. 252 1 p., P-657.

Research output: Contribution to journal › Conference article › peer-review

Open Access

Standards for reporting interventions in clinical trials of cupping (STRICTOC): extending the CONSORT statement

Zhang, X., Tian, R., Lam, W. C., Duan, Y., Liu, F., Zhao, C., Wu, T., Shang, H., Tang, X., Lyu, A. & Bian, Z., 31 Jan 2020, In: Chinese Medicine. 15, 1, 15 p., 10.

Research output: Contribution to journal › Journal article › peer-review

Open Access

15 Citations (Scopus)

Structural Analysis and Identification of False Positive Hits in Luciferase-Based Assays

Yang, Z-Y., Dong, J., Yang, Z-J., Lu, A-P., Hou, T-J. & Cao, D-S., 27 Apr 2020, In: Journal of Chemical Information and Modeling. 60, 4, p. 2031-2043 13 p.

Research output: Contribution to journal › Journal article › peer-review

22 Citations (Scopus)

Synthesis and in vitro evaluation of a bispecific aptamer targeting both Sclerostin and Dickkopf-1 (Abstract)

Zhuo, Z., Ni, S., Zhang, Z., Zhang, N., Yu, Y., Lu, A., Zhang, G. & Zhang, B. T., Nov 2020, In: Journal of Bone and Mineral Research. 35, SI, p. 238 1 p., P-615.

Research output: Contribution to journal › Conference article › peer-review

Open Access

1 Citation (Scopus)

Systematic Modeling of log D_7.4 Based on Ensemble Machine Learning, Group Contribution, and Matched Molecular Pair Analysis

Fu, L., Liu, L., Yang, Z. J., Li, P., Ding, J. J., Yun, Y. H., LYU, A., Hou, T. J. & Cao, D. S., 27 Jan 2020, In: Journal of Chemical Information and Modeling. 60, 1, p. 63-76 14 p.

Research output: Contribution to journal › Journal article › peer-review

35 Citations (Scopus)

The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy–Current progress and future direction

Zhao, Y., Zhang, L. X., Jiang, T., Long, J., Ma, Z. Y., Lu, A. P., Cheng, Y. & Cao, D. S., 1 Oct 2020, In: European Journal of Medicinal Chemistry. 203, 112570.

Research output: Contribution to journal › Review article › peer-review

46 Citations (Scopus)

Uncovering the Complexity Mechanism of Different Formulas Treatment for Rheumatoid Arthritis Based on a Novel Network Pharmacology Model

Wang, K. X., Gao, Y., Lu, C., Li, Y., Zhou, B. Y., Qin, X. M., Du, G. H., Gao, L., Guan, D. G. & Lu, A. P., 10 Jul 2020, In: Frontiers in Pharmacology. 11, 1035.

Research output: Contribution to journal › Journal article › peer-review

Open Access

File

39 Citations (Scopus)

48 Downloads (Pure)

Wang-Bi Capsule Alleviates the Joint Inflammation and Bone Destruction in Mice with Collagen-Induced Arthritis

Cui, H., Shu, H., Fan, D., Wang, X., Zhao, N., Lu, C., Lu, A. & He, X., 19 Mar 2020, In: Evidence-based Complementary and Alternative Medicine. 2020, 7 p., 1015083.

Research output: Contribution to journal › Journal article › peer-review

Open Access

6 Citations (Scopus)

WHO Trial Registration Data Set (TRDS) extension for traditional Chinese medicine 2020: recommendations, explanation, and elaboration

Zhang, X., Lan, L., Chan, J. C. P., Zhong, L. L. D., Cheng, C. W., Lam, W. C., Tian, R., Zhao, C., Wu, T. X., Shang, H. C., Lyu, A. P. & Bian, Z. X., 17 Jul 2020, In: BMC Medical Research Methodology. 20, 1, 14 p., 192.

Research output: Contribution to journal › Journal article › peer-review

Open Access

12 Citations (Scopus)

2019

Anti-Cancer Composition Consisting of Halofuginone and Sesquiterpene Lactone Compounds of Artemisia Apiacea and Use Thereof (Granted)

Bian, Z., Chen, G., Gong, R. H., Yang, D. & Lyu, A., 26 Dec 2019, IPC No. A61-BZ-Halo-US01, Patent No. US 10,973,823, 27 Sept 2016, Priority date 5 Jan 2016, Priority No. 16/067,839

Research output: Patent

A potential next generation sclerostin inhibitor specifically targets sclerostin monomer for bone anabolic therapy with low ardiovascular risk in osteogenesis imperfecta mice (Abstract)

Ren, Q., Xie, D., Yu, Y., Tang, Y., Ni, S., Lu, J., Lu, A., Zhang, G., Chan, S. Y. & Zhang, B. T., Dec 2019, In: Journal of Bone and Mineral Research. 34, S1, p. 47-48 2 p.

Research output: Contribution to journal › Conference article › peer-review

A Potential Next Generation Sclerostin Inhibitor Specifically Targets Sclerostin Monomer for Bone Anabolic Therapy with Low Cardiovascular Risk to Reverse Established Osteoporosis in Ovariectomized Rats (Abstract)

Yu, Y., Ren, Q., Ni, S., Liu, J., Zhong, C., Lu, J., Tang, Y., Li, D., Xie, D., Dai, R., Zhang, H., Dang, L., Lyu, A., Zhang, G., Zhuo, Z., Zhang, Z-K., Zhang, B. T., Wang, L., Li, Y., Wong, K. K., & 1 othersZhai, J., Dec 2019, In: Journal of Bone and Mineral Research. 34, S1, p. 264 1 p.

Research output: Contribution to journal › Conference article › peer-review

Application evaluation of clinical practice guidelines for traditional Chinese medicine: A clinical analysis based on the analytic hierarchy process

Cai, H., Li, H., Zeng, H., Xu, D., Ouyang, W. & LYU, A., 22 Oct 2019, In: BMC Complementary Medicine and Therapies. 19, 1, 277.

Research output: Contribution to journal › Journal article › peer-review

Open Access

4 Citations (Scopus)

Astragalus polysaccharide RAP selectively attenuates paclitaxel-induced cytotoxicity toward RAW 264.7 cells by reversing cell cycle arrest and apoptosis

Bao, W. R., Li, Z., Zhang, Q. W., Li, L. F., Liu, H. B., Ma, E. D. L., Leung, C. H., Lyu, A., Bian, Z. & Han, S. Q. B., 11 Feb 2019, In: Frontiers in Pharmacology. 10, FEB, 1580.

Research output: Contribution to journal › Journal article › peer-review

Open Access

23 Citations (Scopus)

Bushen Yijing Fang Reduces Fall Risk in Late Postmenopausal Women with Osteopenia: A Randomized Double-blind and Placebo-controlled Trial

Zheng, Y., Wang, X., Zhang, Z-K., Guo, B., Dang, L., He, B., Zhang, C., Zhou, J., Shi, W., Zhao, Y., Zhan, H., Xu, Y., Liang, C., Liu, J., Guan, D., Wang, L., Wu, X., Li, J., Zhuo, Z., Lin, Z., & 7 othersQiu, H., Zhong, L., Bian, Z., Shi, Y., Zhang, B-T., Zhang, G. & Lu, A., 14 Feb 2019, In: Scientific Reports. 9, 2089.

Research output: Contribution to journal › Journal article › peer-review

Open Access

7 Citations (Scopus)

Destiny of Dendrobium officinale Polysaccharide after Oral Administration: Indigestible and Nonabsorbing, Ends in Modulating Gut Microbiota

Li, L., Yao, H., Li, X., Zhang, Q., Wu, X., Wong, T., Zheng, H., Fung, H., Yang, B., Ma, D., Leung, C., Zhang, G., Bian, Z., Lu, A. & Han, Q., 29 May 2019, In: Journal of Agricultural and Food Chemistry. 67, 21, p. 5968-5977 10 p.

Research output: Contribution to journal › Journal article › peer-review

117 Citations (Scopus)

Dual-functional liposomes with carbonic anhydrase IX antibody and BR2 peptide modification effectively improve intracellular delivery of cantharidin to treat orthotopic hepatocellular carcinoma mice

Zhang, X., Lin, C., Chan, W., Liu, K., LYU, A., Lin, G., Hu, R., Shi, H., ZHANG, H. Q. & YANG, Z., 12 Sept 2019, In: Molecules. 24, 18, 3332.

Research output: Contribution to journal › Journal article › peer-review

Open Access

14 Citations (Scopus)

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling

Wong, H. L. X., Qin, H. Y., Tsang, S. W., Zuo, X., Che, S., Chow, C. F. W., Li, X., Xiao, H. T., Zhao, L., Huang, T., Lin, C. Y., Kwan, H. Y., Yang, T., Longo, F. M., Lyu, A. & Bian, Z. X., Dec 2019, In: Nature Communications. 10, 1745.

Research output: Contribution to journal › Journal article › peer-review

Open Access

42 Citations (Scopus)

Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: Prediction with network pharmacology and validation in a clinical trial

Zhang, C., Guan, D., Jiang, M., Liang, C., Li, L., Zhao, N., Zha, Q., Zhang, W., Lu, C., Zhang, G., Liu, J. & Lu, A., Dec 2019, In: Chinese Medicine. 14, 10 p., 26.

Research output: Contribution to journal › Journal article › peer-review

Open Access

15 Citations (Scopus)

Efficacy of MaZiRenWan, a Chinese Herbal Medicine, in Patients With Functional Constipation in a Randomized Controlled Trial

Zhong, L. L. D., Cheng, C. W., Kun, W., Dai, L., Hu, D. D., Ning, Z. W., Xiao, H. T., Lin, C. Y., Zhao, L., Huang, T., Tian, K., Chan, K. H., Lam, T. W., Chen, X. R., Wong, C. T., Li, M., Lu, A. P., Wu, J. C. Y. & Bian, Z. X., Jun 2019, In: Clinical Gastroenterology and Hepatology. 17, 7, p. 1303-1310.e18 8 p.

Research output: Contribution to journal › Journal article › peer-review

37 Citations (Scopus)

HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis

Liang, C., Li, J., Lu, C., Xie, D., Liu, J., Zhong, C., Wu, X., Dai, R., Zhang, H., Guan, D., Guo, B., He, B., Li, F., He, X., Zhang, W., Zhang, B. T., Zhang, G. & Lu, A., 8 Oct 2019, In: Nature Communications. 10, 13 p., 4579.

Research output: Contribution to journal › Journal article › peer-review

Open Access

34 Citations (Scopus)

Hong Kong Chinese Medicine Clinical Practice Guideline for Cancer Palliative Care: Pain, Constipation, and Insomnia

Lam, W. C., Zhong, L., Liu, Y., Shi, N., Ng, B., Ziea, E., Bian, Z. & Lu, A., 22 Jan 2019, In: Evidence-based Complementary and Alternative Medicine. 2019, 1038206.

Research output: Contribution to journal › Journal article › peer-review

Open Access

File

20 Citations (Scopus)

66 Downloads (Pure)

ICD-11: Impact on Traditional Chinese Medicine and World Healthcare Systems

Lam, W. C., Lyu, A. & Bian, Z., Oct 2019, In: Pharmaceutical Medicine. 33, 5, p. 373–377 5 p.

Research output: Contribution to journal › Journal article › peer-review

Open Access

58 Citations (Scopus)

Identification of Characteristic Autoantibodies Associated With Deficiency Pattern in Traditional Chinese Medicine of Rheumatoid Arthritis Using Protein Chips

Zhao, H., Zhang, Y., Liu, B., Li, L., Zhang, L., Bao, M., Guo, H., Xu, H., Feng, H., Xiao, L., Yi, W., Yi, J., Chen, P., Lu, C. & Lu, A., 10 Jul 2019, In: Frontiers in Pharmacology. 10, 755.

Research output: Contribution to journal › Journal article › peer-review

Open Access

6 Citations (Scopus)

Identification of constituents affecting the secretion of pro-inflammatory cytokines in LPS-induced U937 cells by UHPLC-HRMS-based metabolic profiling of the traditional Chinese medicine formulation Huangqi Jianzhong Tang

Nöst, X., Pferschy-Wenzig, E. M., Nikles, S., He, X., Fan, D., LYU, A., Yuk, J., Yu, K., Isaac, G. & Bauer, R., 27 Aug 2019, In: Molecules. 24, 17, 3116.

Research output: Contribution to journal › Journal article › peer-review

Open Access

21 Citations (Scopus)

LncRNA HOTAIR-mediated Wnt/β-catenin network modeling to predict and validate therapeutic targets for cartilage damage

Zhou, W., He, X., Chen, Z., Fan, D., Wang, Y., Feng, H., Zhang, G., Lu, A. & Xiao, L., Dec 2019, In: BMC Bioinformatics. 20, 412.

Research output: Contribution to journal › Journal article › peer-review

Open Access

20 Citations (Scopus)

Long-term osteoblast-specific Plekho1 silencing by RNA interference prevents bone formation reduction during aging in safety in both genders (Abstract)

Zhang, Z., Zhuo, Z., Zhang, B-T., Liu, J., Liang, C., Lu, A. & Zhang, G., 23 Sept 2019, In: Journal of Bone and Mineral Research. 34, S1, p. 370-370 1 p.

Research output: Contribution to journal › Conference article › peer-review

Open Access

2 Citations (Scopus)

Methylglyoxal activates osteoclasts through JNK pathway leading to osteoporosis

Lee, K. M., Lee, C. Y., Zhang, G., Lyu, A. & Yue, K. K. M., 1 Aug 2019, In: Chemico-Biological Interactions. 308, p. 147-154 8 p.

Research output: Contribution to journal › Journal article › peer-review

18 Citations (Scopus)

microRNA-Mediated Regulation of Bone Remodeling: A Brief Review

Liu, J., Dang, L., Wu, X., Li, D., Ren, Q., Lu, A. & Zhang, G., Sept 2019, In: JBMR Plus. 3, 9, 9 p., e10213.

Research output: Contribution to journal › Review article › peer-review

Open Access

27 Citations (Scopus)

Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis

He, X., Liu, J., Liang, C., Shaikh, A. B., Zheng, K., Dang, L., Guo, B., Li, D., Lu, C., Guo, Q., Fan, D., Bian, Y., Feng, H., Xiao, L., Pan, X., Xiao, C., Zhang, B. T., Zhang, G. & Lu, A., Mar 2019, In: EBioMedicine. 41, p. 538-555 18 p.

Research output: Contribution to journal › Journal article › peer-review

Open Access

14 Citations (Scopus)

PARP1 interacts with ezrin contributing to metastasis in osteosarcoma

Li, F., Wu, X., Fu, X., Lu, A., Zhang, G. & Lim, N. J., Dec 2019, In: Journal of Bone and Mineral Research. 34, S1, p. 133 1 p.

Research output: Contribution to journal › Conference article › peer-review

Placebo design in WHO-registered trials of Chinese herbal medicine need improvements

Zhang, X., Tian, R., Zhao, C., Tang, X., Lu, A. & Bian, Z., 6 Nov 2019, In: BMC Complementary Medicine and Therapies. 19, 1, 13 p., 299.

Research output: Contribution to journal › Journal article › peer-review

Open Access

21 Citations (Scopus)

Pulmonary delivery of transferrin receptors targeting peptide surface-functionalized liposomes augments the chemotherapeutic effect of quercetin in lung cancer therapy

Riaz, M. K., Zhang, X., Wong, K. H., Chen, H., Liu, Q., Chen, X., Zhang, G., Lu, A. & Yang, Z., 24 Apr 2019, In: International Journal of Nanomedicine. 14, p. 2879-2902 24 p.

Research output: Contribution to journal › Journal article › peer-review

Open Access

75 Citations (Scopus)

Quality assessment of clinical trial registration with traditional Chinese medicine in WHO registries

Zhang, X., Tian, R., Yang, Z., Zhao, C., Yao, L., Lau, C. T., Wu, T., Shang, H., Zhang, X., Lu, A. & Bian, Z., 9 Feb 2019, In: BMJ Open. 9, 2, 14 p., e025218.

Research output: Contribution to journal › Journal article › peer-review

Open Access

21 Citations (Scopus)

Regulatory network reconstruction of five essential microRNAs for survival analysis in breast cancer by integrating miRNA and mRNA expression datasets

He, K., Li, W. X., Guan, D., Gong, M., Ye, S., Fang, Z., Huang, J. F. & Lu, A., 1 Jul 2019, In: Functional and Integrative Genomics. 19, 4, p. 645–658 14 p.

Research output: Contribution to journal › Journal article › peer-review

26 Citations (Scopus)

Aiping LYU, Prof

Research Output

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