Projects per year
Personal profile
Chinese Name
易威伸
Biography
Wei Shen Aik is an Assistant Professor at Hong Kong Baptist University. He obtained his Bachelor of Arts degree in Natural Sciences at the University of Cambridge. He then received his doctoral training in chemical biology at Prof. Christopher Schofield's laboratory at the University of Oxford. After his D.Phil. studies at Oxford, Wei Shen did his postdoctoral research in Structural Biology with Professor Liang Tong at Columbia University in the United States. As group leader, Wei Shen aspires to combine structural biology and chemical biology to design new solutions for human health problems.
Research Interests
Dr. Aik interested in studying protein-nucleic acid complexes in various contexts, such as RNA metabolism, viral replication, and cancer. He is also aspire to be innovative in designing therapies using structures of protein/nucleic acid complexes as guides.
Education/Academic qualification
-, Bachelor, University of Cambridge
Master, University of Cambridge
Chemistry, PhD, University of Oxford
Keywords
- QD Chemistry
- RM Therapeutics. Pharmacology
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Dive into the research topics where Wei Shen AIK is active. Topic labels come from the works of this scholar.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Structural and biochemical characterisation of small GTPase Rab23 and clinical mutants
AIK, W. S. (PI) & HOR, C. H. H. (CoI)
1/01/26 → 31/12/28
Project: Research project
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NAD capping of RNA: mechanism and functions
XIA, Y. (PI), AIK, W. S. (CoPI), CAI, Z. (CoPI), Jiang, L. (CoPI), Wong, K. B. (CoPI) & XIONG, L. (CoPI)
1/05/23 → 30/04/26
Project: Research project
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Structure-based inhibitor development targeting RNA epitranscriptomic modifications
AIK, W. S. (PI)
1/09/19 → 31/08/22
Project: Research project
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A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression
Cheung, J. C. T., Ng, L. W., Zhu, Z., Chen, B., Li, S., Xu, M., Ding, X., Pu, D., Hu, Y., Ren, Y., Kang, W., Li, M., Wong, J. W. H., Wang, X., Cheng, Y. K., Aik, W. S., Wong, K.-L., Ng, S. S. M., Wong, N. & Dong, Y., 14 Nov 2025, In: Cancer Research. 85, 22, p. 4450-4468 19 p.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Development of a Modular Ribonucleoprotein Complex as a General Strategy to Deliver RNAi Therapeutics
Tam, N. Y., Wang, X., Chan, G. C. Y., Kong, W. P., Chau, W. Y., Fu, X., Wong, K. Y., Lung, H. L., Yu, Z. L. & Aik, W. S., 26 Sept 2025, In: Advanced Healthcare Materials. 14, 25, 13 p., e03281.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Evidence human FTO catalyses hydroxylation of N6-methyladenosine without direct formation of a demethylated product contrasting with ALKBH5/2/3 and bacterial AlkB
Kaur, S. (Co-first author), Maheswaran, P. (Co-first author), Kaur, S., Lai, Y., Salah, E., Zhang, D., Shishodia, S., Schofield, C. J. & Aik, W. S., 9 Sept 2025, In: Nucleic Acids Research. 53, 16, 15 p., gkaf813.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Modulator engineering of bifunctional metal-organic framework for synergistic catalysis
Ouyang, J., Tao, H., Yang, Z., Wong, Y. K., Aik, W. S., Ho-Yung Sung, H., Williams, I. D. & Quan, Y., 16 Jan 2025, In: Chem Catalysis. 5, 1, 11 p., 101155.Research output: Contribution to journal › Journal article › peer-review
4 Citations (Scopus) -
Reposition Pathways of GTP in Orthoflavivirus NS5-Methyltransferase Revealed by Enhanced Molecular Dynamics Simulations
Ng, L. W., Cheng, Y. K., Aik, W. S. & Han, W., 28 Jun 2025, In: Physical Chemistry Chemical Physics. 27, 24, p. 12738-12751 14 p.Research output: Contribution to journal › Journal article › peer-review
Open Access
Prizes
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Dean’s Award for Outstanding Achievement 2023 (Early Career Performance)
AIK, W. S. (Recipient), 2023
Prize: Award