Projects per year
Personal profile
Chinese Name
易威伸
Biography
Wei Shen Aik is an Assistant Professor at Hong Kong Baptist University. He obtained his Bachelor of Arts degree in Natural Sciences at the University of Cambridge. He then received his doctoral training in chemical biology at Prof. Christopher Schofield's laboratory at the University of Oxford. After his D.Phil. studies at Oxford, Wei Shen did his postdoctoral research in Structural Biology with Professor Liang Tong at Columbia University in the United States. As group leader, Wei Shen aspires to combine structural biology and chemical biology to design new solutions for human health problems.
Research Interests
Dr. Aik interested in studying protein-nucleic acid complexes in various contexts, such as RNA metabolism, viral replication, and cancer. He is also aspire to be innovative in designing therapies using structures of protein/nucleic acid complexes as guides.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
-, Bachelor, University of Cambridge
Master, University of Cambridge
Chemistry, PhD, University of Oxford
Keywords
- QD Chemistry
- RM Therapeutics. Pharmacology
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Dive into the research topics where Wei Shen AIK is active. Topic labels come from the works of this scholar.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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NAD capping of RNA: mechanism and functions
XIA, Y., AIK, W. S., CAI, Z., Jiang, L., Wong, K. B. & XIONG, L.
1/05/23 → 30/04/26
Project: Research project
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Structure-based inhibitor development targeting RNA epitranscriptomic modifications
1/09/19 → 31/08/22
Project: Research project
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In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome
Yang, X. C., Desotell, A., Lin, M. H., Paige, A. S., Malinowska, A., Sun, Y., Aik, W. S., Dadlez, M., Tong, L. & Dominski, Z., Nov 2023, In: RNA. 29, 11, p. 1673-1690 18 p.Research output: Contribution to journal › Journal article › peer-review
Open Access -
Ribonucleoproteins for RNA Therapeutics Delivery And Gene Silencing
AIK, W. S., 2 Mar 2023, IPC No. C12-AW-U4RN-US01 , 7 Sept 2021, Priority date 7 Sept 2021, Priority No. US17/930,088Research output: Patent
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Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes
Kaur, S., Tam, N. Y., McDonough, M. A., Schofield, C. J. & Aik, W. S., 22 Apr 2022, In: Nucleic Acids Research. 50, 7, p. 4148-4160 13 p.Research output: Contribution to journal › Journal article › peer-review
Open Access36 Citations (Scopus) -
Ribonucleoproteins for RNA Therapeutics Delivery
AIK, W. S., 1 Jan 2022, IPC No. C12-AW-U4RN-TW01, 12 Mar 2021, Priority date 13 Mar 2020, Priority No. TW 110109035Research output: Patent
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Reconstitution and biochemical assays of an active human histone pre-mRNA 3′-end processing machinery
Sun, Y., Aik, W. S., Yang, X. C., Marzluff, W. F., Dominski, Z. & Tong, L., 25 Jun 2021, mRNA 3' End Processing and Metabolism. Tian, B. (ed.). 1st ed. Academic Press Inc., p. 291-324 34 p. (Methods in Enzymology; vol. 655).Research output: Chapter in book/report/conference proceeding › Chapter › peer-review
3 Citations (Scopus)
Prizes
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Dean’s Award for Outstanding Achievement 2023 (Early Career Performance)
AIK, Wei Shen (Recipient), 2023
Prize: Award