School of Chinese Medicine

Finished

腸道微生物與腸道幹細胞在腸易激綜合徵發病機制中的相互作用

WONG, H. L. X. (PI)

1/10/19 → 30/09/22

Project: Research project

基于Wnt/β-catenin通路探讨远志皂苷元的促神经发生作用及其治疗阿尔兹海默病的研究

ZHANG, S. (PI)

1/10/19 → 30/09/22

Project: Research project

基於EGFR/STAT3信號通路探索白朮及其有效成分抗黑色素瘤的機制

FU, X. (PI), ZHU, P. (CoI), LI, J. (CoI), CHOU, J. (CoI) & WANG, Y. (CoI)

1/10/19 → 30/09/22

Project: Research project

粉防己碱衍生物T6缓解阿尔茨海默病的分子机制研究

CHEUNG, K.-H. (PI)

1/10/19 → 30/09/22

Project: Research project

遗传性钙磷代谢障碍对儿童骨骼等器官发育的影响及机制研究

ZHANG, G. (PI)

1/09/19 → 31/08/24

Project: Research project

Investigating the scientific basis behind the ancient processing method of heshouwu by hepatotoxicity assessment and chemical characterization

XU, J. (PI) & ZHAO, Z. (CoI)

1/09/19 → 28/02/23

Project: Research project

Investigating the role of MT1-MMP in the regulation of insulin sensitivity and the therapeutic potential of MT1-MMP inhibition in Type 2 diabetes mellitus

WONG, H. L. X. (PI)

1/07/19 → 30/06/22

Project: Research project

Exploring the regulatory role of MT1-MMP for body weight and the therapeutic potential of MT1-MMP inhibition in obesity

WONG, H. L. X. (PI)

1/05/19 → 30/04/22

Project: Research project

Identification of Natural COX-2 Selective Inhibitors from Medicinal Plant (Saussurea laniceps) for the both Safe and Effective Treatment of Arthritis

CHEN, H. (PI)

1/05/19 → 30/04/22

Project: Research project

基於皮膚組學與靶向遞藥技術的中藥皮膚精准護理產品研發

YANG, Z. (PI)

1/04/19 → 31/03/22

Project: Research project

Does parthenolide overcome vemurafenib resistance by inhibiting heat shock protein 90 in melanoma?

YU, Z. (PI)

1/01/19 → 30/06/21

Project: Research project

The role of osteoblastic CKIP-1 in regulating joint inflammation during rheumatoid arthritis

HE, X. (PI)

1/01/19 → 30/06/21

Project: Research project

Osteosarcoma-specific delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in a patient-derived xenograft model

LI, F. (PI)

1/01/19 → 31/12/22

Project: Research project

基於miR-34b/MET/β-catenin通路探討四君子湯與達卡吧嗪合用抗黑色素瘤的機制

YU, Z. (PI), Li, S. M. (CoI), FU, X. (CoI), AMIN, A. (CoI), Zhao, J. (CoI), WANG, Y. (CoI) & LIU, Y. (CoI)

1/01/19 → 31/12/22

Project: Research project

Astragalus polysaccharide RAP enters Peyer’s patches to initiate immune response through M cell transcytosis via TLR2/4 mediated pathway

HAN, S. Q. B. (PI)

1/01/19 → 31/12/21

Project: Research project

To Develop Arylnaphthalene Lignans as Potent Inhibitors Against HIV through Chemical Synthesis

ZHANG, H. (PI)

1/01/19 → 30/06/21

Project: Research project

Toward the next generation of smart anti-tumor drugs: a highly water-soluble nucleolin aptamer-paclitaxel conjugate with a serum-stable linker for tumor-specific targeting in ovarian cancer

LYU, A. (PI)

1/01/19 → 30/06/22

Project: Research project

Modulation of membrane type 1-matrix metalloproteinase by 3,5,4'-trihydroxybibenzyl, an aromatic dihydrostilbene, against perpetual pancreatic stellate cell activation in pancreatogenic diabetes

ZHANG, H. (PI)

1/01/19 → 31/12/21

Project: Research project

From precision medicine to drug discovery: osteoblast-specific inhibition of Smurf1 activity promotes bone formation in distinctive rats with age-related osteoporosis

ZHANG, G. (PI)

1/01/19 → 31/12/22

Project: Research project

Study of Chinese Medicine Protopine on Attenuating Tau Pathology in Alzheimer's Disease: the Roles of Histone Deacetylase 6

LI, M. (PI)

1/01/19 → 31/12/21

Project: Research project

Exploring the involvement of Hsp90 signaling in the anti-melanoma effects of Flos Chrysanthemi and parthenolide

FU, X. (PI), AMIN, A. (CoI), GUO, H. (CoI), ZHU, P. (CoI), LI, J. (CoI) & CHOU, J. (CoI)

1/01/19 → 31/12/21

Project: Research project

Efficacy of JCM16021 for Irritable Bowel Syndrome: from Basic Mechanism to the Clinical Efficacy Approval in a Randomized Placebo Controlled Large Scale Trial

BIAN, Z. (PI)

1/10/18 → 30/06/21

Project: Research project

A mechanistic study on the role of combinatorial gene regulation in controlling gene expression noise through direct observation on the transcriptional activities in single cells

ZHU, H. (PI) & LYU, A. (PI)

1/10/18 → 30/09/21

Project: Research project

Investigation of Anti-Alzheimer's activity of Protopine derivative for clearing Tau through modulation of HDAC6-Hsp90 interplay and for improving memory via stimulation of RAS-GRF1/ERK pathway

LI, M. (PI)

1/09/18 → 31/08/20

Project: Research project

Electro-acupuncture combined auricular acupressure for central obesity: a single blinded randomized sham-controlled clinical trial

ZHONG, L. (PI)

1/08/18 → 31/01/21

Project: Research project

Correcting presenilin-1 mutation-mediated autophagy deficit in familial Alzheimer's disease by Chinese medicine tetrandrine

CHEUNG, K.-H. (PI)

1/06/18 → 31/05/20

Project: Research project

Caffeic acid inhibits prostate cancer growth and metastasis by inhibiting STAT3 signaling pathway under high fat diet feeding condition

KWAN, H. Y. (PI)

1/05/18 → 30/04/21

Project: Research project

Regulation of microRNA biogenesis by BRAF-MEK targeted therapy: molecular mechanisms and role in drug resistance

YU, Z. (PI)

1/04/18 → 31/03/20

Project: Research project

The role of osteoclastic miR-214-3p in early osteoarthritis development

ZHANG, G. (PI)

1/01/18 → 30/06/20

Project: Research project

To Elucidate the Anti-Ebola Potency of the Active Leads Discovered Based on the Diversified Plants in Lingnan Region of China

ZHANG, H. (PI)

1/01/18 → 30/06/21

Project: Research project

A special perspective to evaluate the toxicity and quality of Yimucao decoction pieces by probing the chemical distribution and change in its different tissues and medicinal parts

ZHAO, Z. (PI)

1/01/18 → 31/12/20

Project: Research project

Contribution of palmitic acid-TLR4 axis in high fat diet-associated colorectal cancer cell proliferation

KWAN, H. Y. (PI)

1/01/18 → 31/05/21

Project: Research project

Study of a novel TFEB activator on attenuating Tau pathology in Alzheimer’s disease

LI, M. (PI)

1/01/18 → 31/12/20

Project: Research project

Preclinical study of the Category I antitumor new drug EN-002 inhibiting the novel targets -- DNA replication initiation protein

YU, Z. (PI)

18/12/17 → 17/12/19

Project: Research project

Synthesis of Acetal Analogs of 11-Oxo-flexicaulin A for Control of Cancer Progression and Metastasis

ZHANG, H. (PI)

1/09/17 → 31/08/19

Project: Research project

Elucidating the involvement of IL-17-IL-6-STAT3 axis in the anti-melanoma effects of a herbal formula comprising Flos Sophorae and Flos Lonicerae

YU, Z. (PI)

1/09/17 → 31/08/19

Project: Research project

Use of ephemeranthoquinone, a naturally occurring penanthraquinone, in the treatment of pancreatic fibrosis in chronic pancreatitis

TSANG, S. W. (PI)

1/08/17 → 31/12/19

Project: Research project

Investigation on the anti-Parkinson's Disease Activity of BIGWISE - a Tianma Gouteng Yin-Derived Molecular Formulation

LI, M. (PI)

1/07/17 → 30/06/19

Project: Research project

Hong Kong Authentication Centre of Valuable Chinese Medicines Limited

HAN, S. Q. B. (PI)

1/04/17 → 31/03/20

Project: Knowledge transfer project

Gihon Biotech Limited

ZHANG, H. (PI)

1/04/17 → 31/03/20

Project: Knowledge transfer project

Understanding the mechanical loading-independent communication from skeletal muscle to bone: the role of muscle-derived exosomal miR-206 in regulating bone formation during muscle atrophy

LIU, J. (PI)

1/01/17 → 31/12/19

Project: Research project

A new tool for linking cultivation conditions with chemical profiles to evaluate Chinese medicinal material germplasm

ZHAO, Z. (PI)

1/01/17 → 31/12/19

Project: Research project

Does aberrantly overexpressed CKIP-1 suppress osteoblast-mediated articular bone repair in inflammatory arthritis？A collagen-induced non-human primate arthritis model

LYU, A. (PI)

1/01/17 → 30/06/19

Project: Research project

Role of osteoclast-derived exosomal miR-214 in regulating osteoblastic bone formation

ZHANG, G. (PI)

1/01/17 → 31/12/20

Project: Research project

Targeting sclerostin to reverse established osteoporosis: Aptamer characterization and evaluation for drug discovery

ZHANG, G. (PI)

1/01/17 → 31/12/18

Project: Research project

Synthetic and Biological Studies of the Novel Plant Cyclopeptides Mavacyocines as Highly Potent Anticancer Agents

ZHANG, H. (PI)

1/01/17 → 30/06/20

Project: Research project

Elucidating the role of TLR4/STAT3 signaling in the antimelanoma effects of atractylenolide II

YU, Z. (PI)

1/12/16 → 30/11/18

Project: Research project

Study on the pharmacological effects and mechanism of action of Young Yum Pill

YU, Z. (PI)

16/10/16 → 15/10/19

Project: Research project

Research on the second development of Yi-Shen-Hua-Shi granules

YU, Z. (PI)

1/10/16 → 30/09/18

Project: Research project

Live Smart in the Modern World with Chinese Medicine Wisdom

ZHAO, Z. (PI)

2/09/16 → 30/04/17

Project: Research project

School of Chinese Medicine

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