Mr. & Mrs. Ko Chi Ming Centre for Parkinson's Disease Research

2023

Real-Time Detection and Visualization of Amyloid-β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer’s Disease

Wang, X., Iyaswamy, A., Xu, D., Krishnamoorthi, S., Sreenivasmurthy, S. G., Yang, Y., Li, Y., Chen, C., Li, M., Li, H-W. & Wong, M. S., 11 Jan 2023, In: ACS applied materials & interfaces. 15, 1, p. 39–47 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

2022

3-Acetylpyridine On-Tissue Paternò–Büchi Derivatization Enabling High Coverage Lipid C═C Location-Resolved MS Imaging in Biological Tissues

Chen, Y., Xie, C., Wang, X., Cao, G., Ru, Y., Song, Y., Iyaswamy, A., Li, M., Wang, J. & Cai, Z., 8 Nov 2022, In: Analytical Chemistry. 94, 44, p. 15367-15376 10 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer’s disease therapy

Sreenivasmurthy, S. G., Iyaswamy, A., Krishnamoorthi, S., Reddi, R. N., Kammala, A. K., Vasudevan, K., Senapati, S., Zhu, Z., Su, C. F., Liu, J., Guan, X. J., Chua, K. K., Cheung, K. H., Chen, H., Zhang, H. J., Zhang, Y., Song, J. X., Kumar Durairajan, S. S. & Li, M., 26 Oct 2022, In: Frontiers in Molecular Biosciences. 9, 1030534.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells

NG, L., WANG, X., YANG, C., SU, C., LI, M. & CHEUNG, A. K. L., 2 Mar 2022, In: Frontiers in Immunology. 13, 17 p., 833515.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy

Yang, C., Su, C., Iyaswamy, A., Krishnamoorthi, S. K., Zhu, Z., Yang, S., Tong, B. C., Liu, J., Sreenivasmurthy, S. G., Guan, X., Kan, Y., Wu, A. J., Huang, A. S., Tan, J., Cheung, K., Song, J. & Li, M., Apr 2022, In: Acta Pharmaceutica Sinica B. 12, 4, p. 1707-1722 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Citations (Scopus)

Chinese herbal medicine treatment based on subgroup differentiation as adjunct therapy for Parkinson’s disease: study protocol of a pilot add-on, randomised, controlled, pragmatic clinical trial

Yuen, S. C. S., Chua, K. K., Zhong, L. L. D., Chan, K. W., Chan, C. K. H., Chan, K. L., Lin, Z., Mok, V., Lau, A. Y. & Li, M., 24 Jan 2022, In: Chinese Medicine. 17, 1, 9 p., 16.

Research output: Contribution to journal › Article › peer-review

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1 Citation (Scopus)

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Corrigendum: Celastrol Downmodulates Alpha-Synuclein-Specific T Cell Responses by Mediating Antigen Trafficking in Dendritic Cells

Ng, L., Wang, X., Yang, C., Su, C., Li, M. & Cheung, A. K. L., 20 May 2022, In: Frontiers in Immunology. 13, 1 p., 907993.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy

Zhu, Z., Liu, L. F., Su, C. F., Liu, J., Tong, B. C. K., Iyaswamy, A., Krishnamoorthi, S., Sreenivasmurthy, S. G., Guan, X. J., Kan, Y. X., Xie, W. J., Zhao, C. L., Cheung, K. H., Lu, J. H., Tan, J. Q., Zhang, H. J., Song, J. X. & Li, M., Oct 2022, In: Acta Pharmacologica Sinica. 43, 10, p. 2511-2526 16 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models

Cai, C. Z., Zhuang, X. X., Zhu, Q., Wu, M. Y., Su, H., Wang, X. J., Iyaswamy, A., Yue, Z., Wang, Q., Zhang, B., Xue, Y., Tan, J., Li, M., He, H. & Lu, J. H., 24 Jan 2022, In: Theranostics. 12, 4, p. 1738-1755 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

Tong, B. C-K., Wu, A. J., Huang, A. S., Dong, R., Malampati, S., Iyaswamy, A., Krishnamoorthi, S., Sreenivasmurthy, S. G., Zhu, Z., Su, C., Liu, J., Song, J., Lu, J. H., Tan, J., Pan, W., Li, M. & Cheung, K-H., 4 Mar 2022, In: Autophagy. 18, 3, p. 624-642 19 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer’s Disease

Guan, X., Iyaswamy, A., Sreenivasmurthy, S. G., Su, C., Zhu, Z., Liu, J., Kan, Y., Cheung, K. H., Lu, J., Tan, J. & Li, M., Apr 2022, In: International Journal of Molecular Sciences. 23, 7, 22 p., 3609.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition

Sreenivasmurthy, S. G., Iyaswamy, A., Krishnamoorthi, S., Senapati, S., Malampati, S., Zhu, Z., Su, C. F., Liu, J., Guan, X. J., Tong, B. C. K., Cheung, K. H., Tan, J. Q., Lu, J. H., Durairajan, S. S. K., Song, J. X. & Li, M., Feb 2022, In: Phytomedicine. 96, 14 p., 153887.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models

Selvarasu, K., Singh, A. K., Iyaswamy, A., Sreenivasmurthy, S. G., Krishnamoorthi, S., Bera, A. K., Huang, J. D. & Durairajan, S. S. K., 25 Oct 2022, In: Frontiers in Molecular Biosciences. 9, 16 p., 1050768.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies

Tong, B. C. K., Huang, A. S., Wu, A. J., Iyaswamy, A., Ho, O. K. Y., Kong, A. H. Y., Sreenivasmurthy, S. G., Zhu, Z., Su, C., Liu, J., Song, J., Li, M. & Cheung, K. H., 22 Oct 2022, In: Journal of Biomedical Science. 29, 19 p., 85.

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8 Citations (Scopus)

3 Downloads (Pure)

TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2

Yang, C. B., Liu, J., Tong, B. C. K., Wang, Z. Y., Zhu, Z., Su, C. F., Sreenivasmurthy, S. G., Wu, J. X., Iyaswamy, A., Krishnamoorthi, S., Huang, S. Y., Cheung, K. H., Song, J. X., Tan, J. Q., Lu, J. H. & Li, M., May 2022, In: Acta Pharmacologica Sinica. 43, 5, p. 1251–1263 13 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models

Iyaswamy, A., Wang, X., Krishnamoorthi, S., Kaliamoorthy, V., Sreenivasmurthy, S. G., Kumar Durairajan, S. S., Song, J-X., Tong, B. C. K., Zhu, Z., Su, C-F., Liu, J., Cheung, K-H., Lu, J-H., Tan, J-Q., Li, H. W., Wong, M. S. & Li, M., May 2022, In: Redox Biology. 51, 21 p., 102280.

Research output: Contribution to journal › Article › peer-review

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30 Citations (Scopus)

2 Downloads (Pure)

Toosendanin, a late-stage autophagy inhibitor, sensitizes triple-negative breast cancer to irinotecan chemotherapy

Zhang, S., Dong, Y., Chen, X., Tan, C. S. H., Li, M., Miao, K. & Lu, J. H., 6 May 2022, In: Chinese Medicine (United Kingdom). 17, 1, 14 p., 55.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Toosendanin, a novel potent vacuolar-type H⁺-translocating ATPase inhibitor, sensitizes cancer cells to chemotherapy by blocking protective autophagy

Dong, Y., Zhu, G., Wang, S. F., Keon, K. A., Rubinstein, J. L., Zeng, S. X., Zhang, S., Chen, Q. L., Fu, J., Li, M., Shen, H. M., Lu, J. J., Chen, X. P. & Lu, J. H., Mar 2022, In: International Journal of Biological Sciences. 18, 7, p. 2684-2702 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

2021

Amyloid-β oligomer targeted theranostic probes for in vivo NIR imaging and inhibition of self-aggregation and amyloid-β induced ROS generation

Wang, X., Wang, C., Chan, H. N., Ashok, I., Krishnamoorthi, S. K., Li, M., Li, H. W. & Wong, R. M. S., 1 Mar 2021, In: Talanta. 224, 121830.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Chronic oral administration of adipoRon reverses cognitive impairments and ameliorates neuropathology in an Alzheimer’s disease mouse model

Ng, R. C. L., Jian, M., Ma, O. K. F., Bunting, M., Kwan, J. S. C., Zhou, G. J., Senthilkumar, K., Iyaswamy, A., Chan, P. K., Li, M., Leung, K. M. Y., Durairajan, S. S. K., Lam, K. S. L., Chu, L. W., Festenstein, R., Chung, S. K. & Chan, K. H., Oct 2021, In: Molecular Psychiatry. 26, 10, p. 5669–5689 21 p.

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson’s Disease

Chen, L., Huang, Y., Yu, X., Lu, J., Jia, W., Song, J., Liu, L., Wang, Y., Huang, Y., Xie, J. & Li, M., 13 Apr 2021, In: Frontiers in Pharmacology. 12, 642900.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Citations (Scopus)

Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB)

Zheng, X., Lin, W., Jiang, Y., Lu, K., Wei, W., Huo, Q., Cui, S., Yang, X., Li, M., Xu, N., Tang, C. & Song, J. X., 2 Nov 2021, In: Autophagy. 17, 11, p. 3833-3847 15 p.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation

Cai, C. Z., Yang, C., Zhuang, X. X., Yuan, N. N., Wu, M. Y., Tan, J. Q., Song, J. X., Cheung, K. H., Su, H., Wang, Y. T., Tang, B. S., Behrends, C., Durairajan, S. S. K., Yue, Z., Li, M. & Lu, J. H., 4 May 2021, In: Autophagy. 17, 5, p. 1112-1130 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease

Iyaswamy, A., Krishnamoorthi, S. K., Zhang, H., SREENIVASA MURTHY, S. G. S., Zhu, Z., Liu, J., Su, C. F., Guan, X. J., Wang, Z. Y., Cheung, K. H., Song, J., Durairajan, S. S. K. & Li, M., Oct 2021, In: Phytomedicine. 91, 153648.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

2020

A curcumin derivative activates TFEB and protects against parkinsonian neurotoxicity in vitro

Wang, Z., Yang, C., Liu, J., Tong, C. K. B., Zhu, Z., Malampati, S., Sreenivasmurthy, S. G., Cheung, K-H., IYASWAMY, A., Su, C., Lu, J., Song, J. & LI, M., 2 Feb 2020, In: International Journal of Molecular Sciences. 21, 4, 1515.

Research output: Contribution to journal › Article › peer-review

Open Access

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31 Citations (Scopus)

4 Downloads (Pure)

A Self-Assembled α-Synuclein Nanoscavenger for Parkinson's Disease

Liu, J., Liu, C., Zhang, J., Zhang, Y., Liu, K., Song, J. X., Sreenivasmurthy, S. G., Wang, Z., Shi, Y., Chu, C., Zhang, Y., Wu, C., Deng, X., Liu, X., Song, J., Zhuang, R., Huang, S., Zhang, P., Li, M., Wen, L., & 2 othersZhang, Y. W. & Liu, G., 25 Feb 2020, In: ACS Nano. 14, 2, p. 1533-1549 17 p.

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models

Song, J. X., Malampati, S., Zeng, Y., Durairajan, S. S. K., Yang, C., Tong, C. K. B., Iyaswamy, A., Shang, W. B., Sreenivasmurthy, S. G., Zhu, Z., Cheung, K-H., Lu, J. H., Tang, C., Xu, N. & Li, M., Feb 2020, In: Aging Cell. 19, 2, e13069.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Citations (Scopus)

A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38

Yang, C., Zhu, Z., Tong, C. K. B., Iyaswamy, A., Xie, W. J., Zhu, Y., Sreenivasmurthy, S. G., Senthilkumar, K., Cheung, K-H., Song, J. X., Zhang, H. & Li, M., May 2020, In: Redox Biology. 32, 101445.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Citations (Scopus)

NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models

Iyaswamy, A., Krishnamoorthi, S. K., Song, J. X., Yang, C. B., Kaliyamoorthy, V., Zhang, H., Sreenivasmurthy, S. G., Malampati, S., Wang, Z. Y., Zhu, Z., Tong, B. C. K., Cheung, K. H., Lu, J. H., Durairajan, S. S. K. & Li, M., Jan 2020, In: Journal of Food and Drug Analysis. 28, 1, p. 132-146 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models

Zhuang, X. X., Wang, S. F., Tan, Y., Song, J. X., Zhu, Z., Wang, Z. Y., Wu, M. Y., Cai, C. Z., Huang, Z. J., Tan, J. Q., Su, H. X., Li, M. & Lu, J. H., 18 Feb 2020, In: Cell Death and Disease. 11, 2, 18 p., 128.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Citations (Scopus)

The Effect of Conduction Exercise and Self-Acupressure in Treatment of Parkinson's Disease: A Pilot Study

Yuen, C. S., Chua, K. K., Lau, W. H., Zhuang, Z. Y., Chow, H. Y. & Li, M., 11 Aug 2020, In: Evidence-based Complementary and Alternative Medicine. 2020, 9 p., 7950131.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

The Effect of Conduction Exercise and Self-Acupressure in Treatment of Parkinson’s Disease: A Pilot Study

Yuen, C. S., Chua, K. K., Lau, W. H., Zhuang, Z. Y., Chow, H. Y. & Li, M., 11 Aug 2020, In: Evidence-based Complementary and Alternative Medicine. 2020, 9 p., 7950131.

Research output: Contribution to journal › Article › peer-review

Open Access

Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer’s Disease

Iyaswamy, A., Krishnamoorthi, S. K., Liu, Y. W., Song, J., Kammala, A. K., Sreenivasmurthy, S. G., Malampati, S., Tong, C. K. B., Selvarasu, K., Cheung, K. H., Lu, J., Tan, J., Huang, C-Y., Durairajan, S. S. K. & Li, M., 30 Oct 2020, In: Frontiers in Pharmacology. 11, 584770.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

2019

Antidiabetic activity and potential mechanism of amentoflavone in diabetic mice

Su, C., Yang, C., Gong, M., Ke, Y., Yuan, P., Wang, X., LI, M., Zheng, X. & Feng, W., 11 Jun 2019, In: Molecules. 24, 11, 2184.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Citations (Scopus)

Natural alkaloid harmine promotes degradation of alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation

Cai, C. Z., Zhou, H. F., Yuan, N. N., Wu, M. Y., Lee, S. M. Y., Ren, J. Y., Su, H. X., Lu, J. J., Chen, X. P., Li, M., Tan, J. Q. & Lu, J. H., Aug 2019, In: Phytomedicine. 61, 152842.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Neuroprotective effects of berberine in animal models of Alzheimer's disease: A systematic review of pre-clinical studies

Yuan, N. N., Cai, C. Z., Wu, M. Y., Su, H. X., Li, M. & Lu, J. H., Dec 2019, In: BMC Complementary and Alternative Medicine. 19, 109.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Citations (Scopus)

Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis

Ji, F., Sreenivasmurthy, S. G., Wei, J., Shao, X., Luan, H., Zhu, L., Song, J., Liu, L., Li, M. & Cai, Z., 15 Oct 2019, In: Journal of Hazardous Materials. 378, 120738.

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Study of metabolic disorders associated with BDE-47 exposure in Drosophila model by MS-based metabolomics

Ji, F., Wei, J., Luan, H., Li, M. & Cai, Z., 30 Nov 2019, In: Ecotoxicology and Environmental Safety. 184, 109606.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

The effect of conduction exercise and self-acupressure in treatment of Parkinson's disease: Protocol for a pilot study

Yuen, C. S., Chua, K. K., Lau, W., Zhuang, Z., Chow, H. Y. & Li, M., Jul 2019, In: Journal of Traditional Chinese Medical Sciences. 6, 3, p. 270-276 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2017

A modified formulation of Huanglian-Jie-Du-Tang reduces memory impairments and β-amyloid plaques in a triple transgenic mouse model of Alzheimer's disease

DURAIRAJAN, S. S. K., IYASWAMY, A., Shetty, S. G., Kammella, A. K., Malampati, S., Shang, W., YANG, C., SONG, J., Chung, S., Huang, J., Ilango, K., HAN, S. Q. B. & LI, M., 24 Jul 2017, In: Scientific Reports. 7, 1, 6238.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

Decrease in the Generation of Amyloid-β Due to Salvianolic Acid B by Modulating BACE1 Activity

Durairajan, S. S. K., Chirasani, V. R., Shetty, S. G., Iyaswamy, A., Malampati, S., Song, J., Liu, L., Huang, J., Senapati, S. & Li, M., Nov 2017, In: Current Alzheimer Research. 14, 11, p. 1229-1237 9 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Occurrence of spleen qi deficiency as defined by Chinese medicine in Parkinson disease

Chua, K. K. & Li, M., Jan 2017, In: Journal of Traditional Chinese Medical Sciences. 4, 1, p. 24-30 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

SONG, J., Sun, Y. R., Peluso, I., Zeng, Y., Yu, X., Lu, J. H., Xu, Z., Wang, M. Z., LIU, L., Huang, Y. Y., Chen, L. L., DURAIRAJAN, S. S. K., ZHANG, H., Zhou, B., ZHANG, H. Q., LYU, A., Ballabio, A., Medina, D. L., Guo, Z. & LI, M., 2 Aug 2016, In: Autophagy. 12, 8, p. 1372-1389 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

115 Citations (Scopus)

Full component analysis of Tianma-Gouteng-Yin

Huang, Y. Y., LIU, L., Yue, R. Q., XU, J., Ho, A., LI, M. & HAN, S. Q. B., 29 Sept 2016, In: Chinese Medicine. 11, 1, 44.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

Urinary Metabolomics Reveals Alterations of Aromatic Amino Acid Metabolism of Alzheimer’s Disease in the Transgenic CRND8 Mice

Tang, Z., Liu, L., Li, Y., Dong, J., Li, M., Huang, J., Lin, S. & Cai, Z., Jul 2016, In: Current Alzheimer Research. 13, 7, p. 764-776 13 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

2015

Hypothesis-driven screening of Chinese herbs for compounds that promote neuroprotection

Friedemann, T., Li, M., Fei, J., Schumacher, U., Song, J. & Schröder, S., 13 Nov 2015, In: Science. 350, 6262, p. S69-S71 3 p.

Research output: Contribution to journal › Article

Mr. & Mrs. Ko Chi Ming Centre for Parkinson's Disease Research

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