Institute of Integrated Bioinformedicine & Translational Science

Research Output

Research output per year 2013 2016 2017 2018 2019 2020 2021 2022 2023 2024 2024

• 103 Journal article
• 28 Review article
• 4 Chapter
• 2 Conference article
• 4 More
  • 2 Editorial
  • 1 Conference paper
  • 1 Preprint

Research output per year

Research output per year

Search results

• 2024

  Aloperine Suppresses Cancer Progression by Interacting with VPS4A to Inhibit Autophagosome-lysosome Fusion in NSCLC

  Guo, W., Zhou, H., Wang, J., Lu, J., Dong, Y., Kang, Z., Qiu, X., Ouyang, X., Chen, Q., Li, J., Cheng, X., Du, K., Li, M., Lin, Z., Jin, M., Zhang, L., Sarapultsev, A., Shi, K., Li, F., Zhang, G., & 8 othersWu, K., Rong, Y., Heissmeyer, V., Liu, Y., Li, Y., Huang, K., Luo, S. & Hu, D., 21 Aug 2024, In: Advanced Science. 11, 31, 21 p., 2308307.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • aloperine 100%
  • Aloperine 99%
  • lysosomes 77%
  • Autophagosomes 60%
  • progressions 55%

• A novel network pharmacology strategy to decode mechanism of Wuling Powder in treating liver cirrhosis

  Liu, Q., Li, X., Li, Y., Luo, Q., Fan, Q., Lu, A., Guan, D. & Li, J., 1 Mar 2024, In: Chinese Medicine (United Kingdom). 19, 1, 17 p., 36.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

• CRISPRa engineered Elite macrophages enable adoptive cell therapy for rheumatoid arthritis

  Huang, Y., Wang, Z., Zhong, C., Chen, H., Chen, X., Cao, C., Qiu, F., Xie, D., Li, J., Li, J., Yang, X., Lu, A., Fu, X. & Liang, C., 20 Mar 2024, In: The Innovation Medicine. 2, 1, 20 p., 100050.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Clustered Regularly Interspaced Short Palindromic Repeats 100%
  • Cell- and Tissue-Based Therapy 82%
  • Interleukins 81%
  • Transcriptional Activation 79%
  • Interleukin-10 77%

• Generation of cytotoxic aptamers specifically targeting fibroblast-like synoviocytes by CSCT-SELEX for treatment of rheumatoid arthritis

  Qiu, F., Xie, D., Chen, H., Wang, Z., Huang, J., Cao, C., Liang, Y., Yang, X., He, D. Y., Fu, X., Lu, A. & Liang, C., 4 Sept 2024, (E-pub ahead of print) In: Annals of the Rheumatic Diseases. 19 p., ard-2024-225565.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

• Host-Gut Microbiota Metabolic Interactions and Their Role in Precision Diagnosis and Treatment of Gastrointestinal Cancers

  Cao, C., Yue, S., Lu, A. & Liang, C., Sept 2024, In: Pharmacological Research. 207, 24 p., 107321.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

• Injectable Ozone-Rich Nanocomposite Hydrogel Loaded with D-Mannose for Anti-Inflammatory and Cartilage Protection in Osteoarthritis Treatment

  Wu, H., Wang, J., Lin, Y., He, W., Hou, J., Deng, M., Chen, Y., Liu, Q., Lu, A., Cui, Z., Guan, D. & Yu, B., 19 Jun 2024, In: Small. 20, 25, 2309597.

  Research output: Contribution to journal › Journal article › peer-review
  2 Citations (Scopus)

• Pan-genome analysis of Streptococcus suis serotype 2 highlights genes associated with virulence and antibiotic resistance

  Zhou, Y., Tu, T., Yao, X., Luo, Y., Yang, Z., Ren, M., Zhang, G., Yu, Y., Lu, A. & Wang, Y., 21 Feb 2024, In: Frontiers in Microbiology. 15, 19 p., 1362316.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Streptococcus suis 100%
  • Microbial Drug Resistance 66%
  • Serogroup 60%
  • Virulence 57%
  • Genome 44%
  1 Citation (Scopus)

• Protocol for constructing tumor-targeting ANM-PROTACs for degradation of transcription factors

  Li, J. & Liang, C., 20 Sept 2024, In: STAR Protocols. 5, 3, 13 p., 103220.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

• Repurposing AS1411 for constructing ANM-PROTACs

  Fu, X., Li, J., Chen, X., Chen, H., Wang, Z., Qiu, F., Xie, D., Huang, J., Yue, S., Cao, C., Liang, Y., Lu, A. & Liang, C., 18 Jul 2024, In: Cell Chemical Biology. 31, 7, p. 1290-1304.e7

  Research output: Contribution to journal › Journal article › peer-review
  2 Citations (Scopus)

• Screening of the key response component groups and mechanism verification of Huangqi-Guizhi-Wuwu-Decoction in treating rheumatoid arthritis based on a novel computational pharmacological model

  Liu, Q., Luo, Q., Fan, Q., Li, Y., Lu, A. & Guan, D., 2 Jan 2024, In: BMC Complementary Medicine and Therapies. 24, 1, 15 p., 4.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • guizhi decoction 100%
  • Rheumatoid Arthritis 43%
  • Pharmacology 34%
  • Encyclopedias 26%
  • 6-paradol 21%

• Unique quinoline orientations shape the modified aptamer to sclerostin for enhanced binding affinity and bone anabolic potential

  Gubu, A., Ma, Y., Yu, S., Zhang, H., Chen, Z., Ni, S., Abdullah, R., Xiao, H., Zhang, Y., Dai, H., Luo, H., Yu, Y., Wang, L., Jiang, H., Zhang, N., Tian, Y., Li, H., Lu, A., Zhang, B. & Zhang, G., 12 Mar 2024, In: Molecular Therapy Nucleic Acids. 35, 1, 14 p., 102146.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • quinoline 100%
  • Anabolic 99%
  • Quinoline 68%
  • Kd 53%
  • Shape 45%
  1 Citation (Scopus)
• 2023

  A20 haploinsufficiency caused by loss-of-function TNFAIP3 mutation likely leads to progression of antiphospholipid syndrome to marginal zone lymphomas following coronavirus disease 2019 vaccination: A case study

  Li, J., Fu, X., Xu, H., Li, B., Nie, L., Ji, L. & Liang, C., Apr 2023, In: Clinical and Translational Discovery. 3, 2, 6 p., e181.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

• A Metabolic Driven Bio-Responsive Hydrogel Loading Psoralen for Therapy of Rheumatoid Arthritis

  Wang, K., Yin, C., Ye, X., Chen, Q., Wu, J., Chen, Y., Li, Y., Wang, J., Duan, C., Lu, A. & Guan, D., 24 May 2023, In: Small. 19, 21, 2207319.

  Research output: Contribution to journal › Journal article › peer-review

  • Psoralen 100%
  • Ficusin 99%
  • Hydrogels 91%
  • Metalloproteases 67%
  • Rheumatoid Arthritis 58%
  5 Citations (Scopus)

• Decoding the key compounds and mechanism of Shashen Maidong decoction in the treatment of lung cancer

  Cai, J., Chen, Y., Wang, K., Li, Y., Wu, J., Yu, H., Li, Q., Wu, Q., Meng, W., Wang, H., Lu, A., Huang, M., Wei, G. & Guan, D., 15 May 2023, In: BMC Complementary Medicine and Therapies. 23, 1, 15 p., 158.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Lung Neoplasms 100%
  • Gene Ontology 41%
  • Chinese Traditional Medicine 38%
  • paeonol 30%
  • protocatechuic acid 28%
  3 Citations (Scopus)

• Development of a Real-Time TaqMan RT-PCR Assay for the Detection of NADC34-like Porcine Reproductive and Respiratory Syndrome Virus

  Tu, T., Pang, M., Jiang, D., Zhou, Y., Wu, X., Yao, X., Luo, Y., Yang, Z., Ren, M., Lu, A., Zhang, G., Yu, Y. & Wang, Y., 6 Apr 2023, In: Veterinary Sciences. 10, 4, 11 p., 279.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Porcine respiratory and reproductive syndrome virus 100%
  • Porcine reproductive and respiratory syndrome virus 90%
  • reverse transcriptase polymerase chain reaction 54%
  • Polymerase Chain Reaction 41%
  • assays 37%
  2 Citations (Scopus)

• Improved GNNs for Log D_7.4 Prediction by Transferring Knowledge from Low-Fidelity Data

  Duan, Y-J., Fu, L., Zhang, X-C., Long, T-Z., He, Y-H., Liu, Z-Q., Lu, A-P., Deng, Y-F., Hsieh, C-Y., Hou, T-J. & Cao, D-S., 24 Apr 2023, In: Journal of Chemical Information and Modeling. 63, 8, p. 2345-2359 15 p.

  Research output: Contribution to journal › Journal article › peer-review

  • neural network 100%
  • Lipophilicity 89%
  • Halogen 74%
  • Indicator 73%
  • Pharmacological Metabolism 65%
  9 Citations (Scopus)

• In-silico target prediction by ensemble chemogenomic model based on multi-scale information of chemical structures and protein sequences

  Yang, S-Q., Zhang, L-X., Ge, Y-J., Zhang, J-W., Hu, J-X., Shen, C-Y., Lu, A-P., Hou, T-J. & Cao, D-S., 23 Apr 2023, In: Journal of Cheminformatics. 15, 1, 14 p., 48.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Statistical Ensemble 100%
  • Proteins 92%
  • proteins 80%
  • predictions 53%
  • Protein 41%
  4 Citations (Scopus)

• Pan-genome wide association study of Glaesserella parasuis highlights genes associated with virulence and biofilm formation

  Zhou, Y., Jiang, D., Yao, X., Luo, Y., Yang, Z., Ren, M., Zhang, G., Yu, Y., Lu, A. & Wang, Y., 17 Apr 2023, In: Frontiers in Microbiology. 14, 22 p., 1160433.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Biofilms 93%
  • Virulence 83%
  • Genome 43%
  • Genes 38%
  1 Citation (Scopus)

• Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation

  Zhou, C., Yu, T., Zhu, R., Lu, J., Ouyang, X., Zhang, Z., Chen, Q., Li, J., Cui, J., Jiang, F., Jin, K. Y., Sarapultsev, A., Li, F., Zhang, G., Luo, S. & Hu, D., 27 Feb 2023, In: International Journal of Biological Sciences. 19, 5, p. 1471-1489 19 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • timosaponin AIII 100%
  • Phospholipid Hydroperoxide Glutathione Peroxidase 78%
  • Ferroptosis 76%
  • phospholipid-hydroperoxide glutathione peroxidase 74%
  • heat shock 69%
  41 Citations (Scopus)
• 2022

  An Integrative Pharmacology Model for Decoding the Underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid Arthritis

  Wu, J., Wang, K., Liu, Q., Li, Y., Huang, Y., Liu, Y., Cai, J., Yin, C., Li, X., Yu, H., Meng, W., Wang, H., Lu, A., Li, Y. & Guan, D., 23 Feb 2022, In: Frontiers in Pharmacology. 13, 801350.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • ermiao 100%
  • Powders 45%
  • Rheumatoid Arthritis 37%
  • Pharmacology 30%
  • Chinese Traditional Medicine 28%
  7 Citations (Scopus)

• A Rapid Protocol for Direct Isolation of Osteoclast Lineage Cells from Mouse Bone Marrow

  Dang, L., Li, N., Wu, X., Li, D., Zhang, Z., Zhang, B. T., Lyu, A., Chen, L., Zhang, G. & Liu, J., 5 Mar 2022, In: Bio-protocol. 12, 5, e4338.

  Research output: Contribution to journal › Journal article › peer-review

  • osteoclasts 100%
  • bone marrow 77%
  • Osteoclasts 74%
  • Bone Marrow Cells 68%
  • protocols 51%

• Beneficial Effects of Celastrol on Immune Balance by Modulating Gut Microbiota in Experimental Ulcerative Colitis Mice

  Li, M., Guo, W., Dong, Y., Wang, W., Tian, C., Zhang, Z., Yu, T., Zhou, H., Gui, Y., Xue, K., Li, J., Jiang, F., Sarapultsev, A., Wang, H., Zhang, G., Luo, S., Fan, H. & Hu, D., Apr 2022, In: Genomics, Proteomics and Bioinformatics. 20, 2, p. 288-303 16 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Celastrol 100%
  • tripterine 89%
  • Mouse 70%
  • Gastrointestinal Microbiome 54%
  • Ulcerative Colitis 54%
  20 Citations (Scopus)

• Berberine ameliorates DSS-induced intestinal mucosal barrier dysfunction through microbiota-dependence and Wnt/β-catenin pathway

  Dong, Y., Fan, H., Zhang, Z., Jiang, F., Li, M., Zhou, H., Guo, W., Zhang, Z., Kang, Z., Gui, Y., Shou, Z., Li, J., Zhu, R., Fu, Y., Sarapultsev, A., Wang, H., Luo, S., Zhang, G. & Hu, D., 16 Jan 2022, In: International Journal of Biological Sciences. 18, 4, p. 1381-1397 17 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • catenins 100%
  • berberine 82%
  • Berberine 80%
  • Catenins 75%
  • Wnt Signaling Pathway 68%
  72 Citations (Scopus)

• Computational Metabolomics Reveals the Potential Mechanism of Matrine Mediated Metabolic Network Against Hepatocellular Carcinoma

  Wang, K., Ye, X., Yin, C., Ren, Q., Chen, Y., Qin, X., Duan, C., Lu, A., Gao, L. & Guan, D., 22 Jul 2022, In: Frontiers in Cell and Developmental Biology. 10, 13 p., 859236.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • matrine 100%
  • Metabolomics 69%
  • Metabolic Networks and Pathways 63%
  • Hepatocellular Carcinoma 51%
  • Computational Biology 16%
  3 Citations (Scopus)

• Mathematical algorithm–based identification of the functional components and mechanisms in depression treatment: An example of Danggui-Shaoyao-San

  Gong, W., Wang, K., Wang, X., Chen, Y., Qin, X., Lu, A. & Guan, D., 22 Aug 2022, In: Frontiers in Cell and Developmental Biology. 10, 17 p., 937621.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • danggui-shaoyao-san 100%
  • Chinese Traditional Medicine 52%
  • Depression 32%
  • Antidepressive Agents 14%
  • Psychomotor Disorders 12%
  1 Citation (Scopus)

• Pancreatic Cancer: Nucleic Acid Drug Discovery and Targeted Therapy

  Dai, H., Abdullah, R., Wu, X., Li, F., Ma, Y., Lu, A. & Zhang, G., 16 May 2022, In: Frontiers in Cell and Developmental Biology. 10, 17 p., 855474.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Drug Discovery 100%
  • Nucleic Acids 95%
  • Pancreatic Neoplasms 92%
  • Nucleotide Aptamers 28%
  • Pharmaceutical Preparations 24%
  7 Citations (Scopus)

• Pushing the Boundaries of Molecular Property Prediction for Drug Discovery with Multitask Learning BERT Enhanced by SMILES Enumeration

  Zhang, X-C., Wu, C-K., Yi, J-C., Zeng, X-X., Yang, C-Q., Lu, A-P., Hou, T-J. & Cao, D-S., 15 Dec 2022, In: Research. 2022, 14 p., 0004.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Drug Discovery 100%
  • Multi-task learning 99%
  • Specifications 47%
  • Deep learning 26%
  • Tuning 23%
  19 Citations (Scopus)

• Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer

  Zhang, X., Wang, K., Dai, H., Cai, J., Liu, Y., Yin, C., Wu, J., Li, X., Wu, G., Lu, A., Liu, Q. & Guan, D., 20 Oct 2022, In: Frontiers in Pharmacology. 13, 29 p., 1018273.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Primulaceae 100%
  • Tripterygium 82%
  • Chinese Traditional Medicine 58%
  • Prescriptions 46%
  • Lung Neoplasms 43%
  8 Citations (Scopus)

• Taraxasterol Inhibits Tumor Growth by Inducing Apoptosis and Modulating the Tumor Microenvironment in Non-Small Cell Lung Cancer

  Lu, J., Shuai, B., Shou, Z., Guo, W., Zhou, C., Ouyang, X., Zhou, H., Li, J., Cui, J., Jiang, F., Jin, K. Y., Sarapultsev, A., Li, F., Zhang, G., Luo, S. & Hu, D., 1 Oct 2022, In: Cancers. 14, 19, 21 p., 4645.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • taraxasterol 100%
  • Tumor Microenvironment 52%
  • Non-Small Cell Lung Carcinoma 45%
  • Apoptosis 30%
  • Growth 25%
  6 Citations (Scopus)

• Targeted Delivery of Chemotherapeutic Agents for Osteosarcoma Treatment

  Xie, D., Wang, Z., Li, J., Guo, D. A., Lu, A. & Liang, C., 4 Mar 2022, In: Frontiers in Oncology. 12, 14 p., 843345.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Osteosarcoma 100%
  • Ligands 33%
  • Therapeutic Human Experimentation 32%
  • Bone Neoplasms 29%
  • Adjuvant Chemotherapy 24%
  17 Citations (Scopus)

• Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation

  Yu, Y., Wang, L., Ni, S., Li, D., Liu, J., Chu, H. Y., Zhang, N., Sun, M., Li, N., Ren, Q., Zhuo, Z., Zhong, C., Xie, D., Li, Y., Zhang, Z. K., Zhang, H., Li, M., Zhang, Z., Chen, L., Pan, X., & 5 othersXia, W., Zhang, S., Lu, A., Zhang, B. T. & Zhang, G., 22 Jul 2022, In: Nature Communications. 13, 16 p., 4241.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • osteogenesis 100%
  • Angiotensin II 82%
  • Osteogenesis 57%
  • cardiovascular system 55%
  • Protective 54%
  116 Citations (Scopus)

• Therapeutic aptamer targeting sclerostin loop3 for promoting bone formation without increasing cardiovascular risk in osteogenesis imperfecta mice

  Wang, L., Yu, Y., Ni, S., Li, D., Liu, J., Xie, D., Chu, H. Y., Ren, Q., Zhong, C., Zhang, N., Li, N., Sun, M., Zhang, Z. K., Zhuo, Z., Zhang, H., Zhang, S., Li, M., Xia, W., Zhang, Z., Chen, L., & 5 othersShang, P., Pan, X., Lu, A., Zhang, B. T. & Zhang, G., 18 Jul 2022, In: Theranostics. 12, 13, p. 5645-5674 30 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Osteogenesis Imperfecta 100%
  • Osteogenesis 66%
  • Apolipoproteins E 29%
  • Aortic Aneurysm 21%
  • Cardiovascular System 18%
  55 Citations (Scopus)

• Uncovering Hidden Mechanisms of Different Prescriptions Treatment for Osteoporosis via Novel Bioinformatics Model and Experiment Validation

  Liu, Y., Liu, Q., Yin, C., Li, Y., Wu, J., Chen, Q., Yu, H., Lu, A. & Guan, D., 8 Feb 2022, In: Frontiers in Cell and Developmental Biology. 10, 831894.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Computational Biology 100%
  • Osteoporosis 94%
  • Prescriptions 89%
  • gushukang 46%
  • er-xian decoction 43%
  7 Citations (Scopus)
• 2021

  015 Modulating melatonin dynamics at transcription level using virtual knockout approaches: an advanced perspective in sleep medicine

  Chowdhury, D., Yip, H. F., Wang, C., Tai, X. C. & Lu, A., May 2021, In: Sleep. 44, suppl. 2, p. A8 1 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

• A metabolic data-driven systems pharmacology strategy for decoding and validating the mechanism of Compound Kushen Injection against HCC

  Wang, K. X., Chen, Y. P., Lu, A., Du, G. H., Qin, X. M., GUAN, D. & Gao, L., 28 Jun 2021, In: Journal of Ethnopharmacology. 274, 114043.

  Research output: Contribution to journal › Journal article › peer-review

  • kushen 100%
  • Metabolic 43%
  • Hepatocellular Carcinoma 43%
  • Pharmacology 35%
  • Injections 30%
  9 Citations (Scopus)

• Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model

  Yang, L., Fan, L., Wang, K., Chen, Y., Liang, L., Qin, X., Lu, A., Cao, P., Yu, B., Guan, D. & Peng, J., 21 Jun 2021, In: Oxidative Medicine and Cellular Longevity. 2021, 20 p., 6641838.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • er-xian decoction 100%
  • Teriparatide 51%
  • Osteoporosis Treatment 47%
  • Osteoporosis 43%
  • Selective Estrogen Receptor Modulator 39%
  32 Citations (Scopus)

• A System Pharmacology Model for Decoding the Synergistic Mechanisms of Compound Kushen Injection in Treating Breast Cancer

  Li, Y., Wang, K., Chen, Y., Cai, J., Qin, X., Lu, A., Guan, D., Qin, G. & Chen, W., 16 Nov 2021, In: Frontiers in Pharmacology. 12, 18 p., 723147.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • kushen 100%
  • Pharmacology 35%
  • Breast Neoplasms 34%
  • Therapeutic Index 32%
  • Injections 30%

• Computational Network Pharmacology–Based Strategy to Capture Key Functional Components and Decode the Mechanism of Chai-Hu-Shu-Gan-San in Treating Depression

  Wang, K., Li, K., Chen, Y., Wei, G., Yu, H., Li, Y., Meng, W., Wang, H., Gao, L., Lu, A., Peng, J. & Guan, D., 12 Nov 2021, In: Frontiers in Pharmacology. 12, 17 p., 782060.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Bupleurum 100%
  • Chinese Traditional Medicine 63%
  • Computational Biology 22%
  • Proteins 13%
  • Therapeutic Uses 9%
  7 Citations (Scopus)

• Detecting Critical Functional Ingredients Group and Mechanism of Xuebijing Injection in Treating Sepsis

  Wu, Q., Yin, C. H., Li, Y., Cai, J. Q., Yang, H. Y., Huang, Y. Y., Zheng, Y. X., Xiong, K., Yu, H. L., Lu, A. P., Wang, K. X., Guan, D. G. & Chen, Y. P., 6 Dec 2021, In: Frontiers in Pharmacology. 12, 30 p., 769190.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Xuebijing 100%
  • Sepsis 44%
  • Chinese Traditional Medicine 35%
  • Injections 31%
  • Genes 22%
  7 Citations (Scopus)

• Exosomal transfer of osteoclast-derived miRNAs to chondrocytes contributes to osteoarthritis progression

  Liu, J., Wu, X., Lu, J., Huang, G., Dang, L., Zhang, H., Zhong, C., Zhang, Z., Li, D., Li, F., Liang, C., Yu, Y., Zhang, B. T., Chen, L., Lu, A. & Zhang, G., 15 Apr 2021, In: Nature Aging. 1, 4, p. 368–384 17 p.

  Research output: Contribution to journal › Journal article › peer-review

  • Osteoclasts 100%
  • Chondrocytes 98%
  • Osteoarthritis 86%
  • MicroRNAs 81%
  • Exosomes 38%
  31 Citations (Scopus)

• QSAR-assisted-MMPA to expand chemical transformation space for lead optimization

  Fu, L., Yang, Z. Y., Yang, Z. J., Yin, M. Z., Lu, A. P., Chen, X., Liu, S., Hou, T. J. & Cao, D. S., Sept 2021, In: Briefings in Bioinformatics. 22, 5, 13 p., bbaa374.

  Research output: Contribution to journal › Journal article › peer-review

  • Quantitative Structure-Activity Relationship 100%
  • Matched-Pair Analysis 95%
  • Lead 67%
  • Pharmaceutical Chemistry 33%
  • Data Accuracy 25%
  13 Citations (Scopus)

• Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications

  Ni, S., Zhuo, Z., Pan, Y., Yu, Y., Li, F., Liu, J., Wang, L., Wu, X., Li, D., Wan, Y., Zhang, L., Yang, Z., Zhang, B-T., Lu, A. & Zhang, G., 3 Mar 2021, In: ACS Applied Materials and Interfaces. 13, 8, p. 9500-9519 20 p.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  File

  • Monoclonal antibodies 100%
  • Oligonucleotides 95%
  • Chemical modification 95%
  • Molecules 62%
  • Modification 35%
  326 Citations (Scopus)

  368 Downloads (Pure)

• The Roles of Sclerostin in Immune System and the Applications of Aptamers in Immune-Related Research

  Sun, M., Chen, Z., Wu, X., Yu, Y., Wang, L., Lu, A., Zhang, G. & Li, F., 25 Feb 2021, In: Frontiers in Immunology. 12, 10 p., 602330.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Immune System Diseases 100%
  • Immune System 74%
  • Oligonucleotides 48%
  • Nucleic Acids 46%
  • Osteogenesis 41%
  6 Citations (Scopus)

• Toward Overcoming Treatment Failure in Rheumatoid Arthritis

  Wang, Z., Huang, J., Xie, D., He, D., Lu, A. & Liang, C., 23 Dec 2021, In: Frontiers in Immunology. 12, 34 p., 755844.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Antirheumatic Agents 100%
  • Treatment Failure 97%
  • Rheumatoid Arthritis 83%
  • Precision Medicine 36%
  • Big Data 22%
  20 Citations (Scopus)

• Weight changes in hypertensive patients with phlegm-dampness syndrome: an integrated proteomics and metabolomics approach

  Zhang, C., Li, L., Cheng, S., Chowdhury, D., Tan, Y., Liu, X., Zhao, N., He, X., Jiang, M., Lu, C. & Lyu, A., 7 Jul 2021, In: Chinese Medicine. 16, 14 p., 54.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Metabolomics 100%
  • Proteomics 83%
  • Hypertension 58%
  • Weights and Measures 57%
  • Phosphatidylcholines 44%
• 2020

  A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA–mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice

  Zhuo, Z., Wan, Y., Guan, D., Ni, S., Wang, L., Zhang, Z., Liu, J., Liang, C., Yu, Y., Lu, A., Zhang, G. & Zhang, B-T., Jul 2020, In: Advanced Science. 7, 13, 22 p., 1903451.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • AAA Domain 100%
  • phenotype 98%
  • Drug Discovery 93%
  • TNF Receptor-Associated Factor 3 90%
  • mice 72%
  114 Citations (Scopus)

• A Novel Network Pharmacology Strategy to Decode Mechanism of Lang Chuang Wan in Treating Systemic Lupus Erythematosus

  Gao, Y., Wang, K. X., Wang, P., Li, X., Chen, J. J., Zhou, B. Y., Tian, J. S., Guan, D., Qin, X. M. & Lyu, A., 2 Oct 2020, In: Frontiers in Pharmacology. 11, 512877.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Systemic Lupus Erythematosus 100%
  • Chinese Traditional Medicine 90%
  • Pharmacology 70%
  • Proteins 39%
  • Pharmaceutical Preparations 35%
  22 Citations (Scopus)

• A Novel Strategy for Decoding and Validating the Combination Principles of Huanglian Jiedu Decoction From Multi-Scale Perspective

  Wang, K. X., Gao, Y., Gong, W. X., Ye, X. F., Fan, L. Y., Wang, C., Gao, X. F., Gao, L., Du, G. H., Qin, X. M., Lyu, A. & Guan, D., 4 Dec 2020, In: Frontiers in Pharmacology. 11, 567088.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • huanglian-jie-du decoction 100%
  • Chinese Traditional Medicine 22%
  • Proteins 15%
  • Protein Interaction Maps 12%
  • Pharmaceutical Preparations 12%
  19 Citations (Scopus)

• A PD-L1 aptamer selected by loss-gain cell-SELEX conjugated with paclitaxel for treating triple-negative breast cancer

  Wu, X., Li, F., Li, Y., Yu, Y., Liang, C., Zhang, B., Zhao, C., Lu, A. & Zhang, G., 23 Jun 2020, In: Medical Science Monitor. 26, 10 p., e925583.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms 100%
  • Paclitaxel 83%
  • Nucleotide Aptamers 26%
  • T-Lymphocytes 17%
  • 130-nm albumin-bound paclitaxel 14%
  26 Citations (Scopus)

• Disorders of Calcium and Phosphorus Metabolism and the Proteomics/Metabolomics-Based Research

  Sun, M., Wu, X., Yu, Y., Wang, L., Xie, D., Zhang, Z., Chen, L., Lu, A., Zhang, G. & Li, F., 10 Sept 2020, In: Frontiers in Cell and Developmental Biology. 8, 13 p., 576110.

  Research output: Contribution to journal › Journal article › peer-review

  Open Access

  File

  • Phosphorus Metabolism Disorders 100%
  • Calcium Metabolism Disorders 85%
  • Metabolomics 55%
  • Proteomics 46%
  • Phosphorus 35%
  38 Citations (Scopus)

  61 Downloads (Pure)