Centre for Chinese Herbal Medicine Drug Development Limited

2022

CRISPR-Cas9 library screening approach for anti-cancer drug discovery: overview and perspectives

Chan, Y. T., Lu, Y., Wu, J., Zhang, C., Tan, H. Y., Bian, Z. X., Wang, N. & Feng, Y., 11 Apr 2022, In: Theranostics. 12, 7, p. 3329-3344 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

34 Citations (Scopus)

Emerging pharmacotherapy for inflammatory bowel diseases

Luo, H., Cao, G., Luo, C., Tan, D., Vong, C. T., Xu, Y., Wang, S., Lu, H., Wang, Y. & Jing, W., Apr 2022, In: Pharmacological Research. 178, 106146.

Research output: Contribution to journal › Review article › peer-review

53 Citations (Scopus)

Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: Helping to fight against cancer via multiple targets

Zhong, Z., Vong, C. T., Chen, F., Tan, H., Zhang, C., Wang, N., Cui, L., Wang, Y. & Feng, Y., May 2022, In: Medicinal Research Reviews. 42, 3, p. 1246-1279 34 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

58 Citations (Scopus)

2021

Edible and Herbal Plants for the Prevention and Management of COVID-19

Li, S., Cheng, C. S., Zhang, C., Tang, G. Y., Tan, H. Y., Chen, H. Y., Wang, N., Lai, A. Y. K. & Feng, Y., 28 Apr 2021, In: Frontiers in Pharmacology. 12, 13 p., 656103.

Research output: Contribution to journal › Review article › peer-review

Open Access

23 Citations (Scopus)

Efficacy of Herbal Medicines Intervention for Colorectal Cancer Patients With Chemotherapy-Induced Gastrointestinal Toxicity — a Systematic Review and Meta-Analysis

Chen, Y., Cheng, C. S., Tan, H. Y., Tam, C. W., Wang, N. & Feng, Y., 25 Mar 2021, In: Frontiers in Oncology. 11, 20 p., 629132.

Research output: Contribution to journal › Review article › peer-review

Open Access

14 Citations (Scopus)

Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids

He, Y., Zhu, L., Ma, J. & Lin, G., Jun 2021, In: Archives of Toxicology. 95, 6, p. 1917-1942 26 p.

Research output: Contribution to journal › Review article › peer-review

45 Citations (Scopus)

Phytochemicals as regulators of Th17/Treg balance in inflammatory bowel diseases

Chang, Y., Zhai, L., Peng, J., Wu, H., Bian, Z. & Xiao, H., Sept 2021, In: Biomedicine and Pharmacotherapy. 141, 111931.

Research output: Contribution to journal › Review article › peer-review

Open Access

49 Citations (Scopus)

Role of Autophagy in the Maintenance of Stemness in Adult Stem Cells: A Disease-Relevant Mechanism of Action

Chen, S., Wang, W., Tan, H. Y., Lu, Y., Li, Z., Qu, Y., Wang, N. & Wang, D., 3 Aug 2021, In: Frontiers in Cell and Developmental Biology. 9, 715200.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Citations (Scopus)

Systematic Review with Meta-Analysis: Effectiveness and Safety of Acupuncture as Adjuvant Therapy for Side Effects Management in Drug Therapy-Receiving Breast Cancer Patients

Chan, Y. T., Wang, N., Tam, C. W., Tan, H. Y., Lu, Y., So, T. H., Yu, E. C. L., Lao, L. & Feng, Y., 12 Oct 2021, In: Evidence-based Complementary and Alternative Medicine. 2021, 15 p., 9949777.

Research output: Contribution to journal › Review article › peer-review

Open Access

4 Citations (Scopus)

2020

Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

Lu, Y., Chan, Y. T., Tan, H. Y., Li, S., Wang, N. & Feng, Y., 27 Apr 2020, In: Molecular Cancer. 19, 16 p., 79.

Research output: Contribution to journal › Review article › peer-review

Open Access

293 Citations (Scopus)

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

Xu, Y., Wang, N., Tan, H. Y., Li, S., Zhang, C. & Feng, Y., 21 Feb 2020, In: Frontiers in Microbiology. 11, 12 p., 219.

Research output: Contribution to journal › Review article › peer-review

Open Access

291 Citations (Scopus)

Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application

Xu, Y., Guo, W., Zhang, C., Chen, F., Tan, H. Y., Li, S., Wang, N. & Feng, Y., 12 May 2020, In: Frontiers in Pharmacology. 11, 19 p., 601.

Research output: Contribution to journal › Review article › peer-review

Open Access

91 Citations (Scopus)

Targeting Cancer Metabolism to Resensitize Chemotherapy: Potential Development of Cancer Chemosensitizers from Traditional Chinese Medicines

Guo, W., Tan, H. Y., Chen, F., Wang, N. & Feng, Y., Feb 2020, In: Cancers. 12, 2, 21 p., 404.

Research output: Contribution to journal › Review article › peer-review

Open Access

48 Citations (Scopus)

Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?

Chan, Y. T., Wang, N., Tan, H. Y., Li, S. & Feng, Y., 30 Apr 2020, In: Frontiers in Pharmacology. 11, 16 p., 548.

Research output: Contribution to journal › Review article › peer-review

Open Access

39 Citations (Scopus)

The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases

Zhang, D., Li, S., Wang, N., Tan, H. Y., Zhang, Z. & Feng, Y., 25 Feb 2020, In: Frontiers in Microbiology. 11, 14 p., 301.

Research output: Contribution to journal › Review article › peer-review

Open Access

289 Citations (Scopus)

The functional role of long noncoding RNA in resistance to anticancer treatment

Qu, Y., Tan, H. Y., Chan, Y. T., Jiang, H., Wang, N. & Wang, D., Jan 2020, In: Therapeutic Advances in Medical Oncology. 12, 18 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

33 Citations (Scopus)

The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism

Li, S., Xu, Y., Guo, W., Chen, F., Zhang, C., Tan, H. Y., Wang, N. & Feng, Y., 24 Mar 2020, In: Frontiers in Pharmacology. 11, 20 p., 351.

Research output: Contribution to journal › Review article › peer-review

Open Access

40 Citations (Scopus)

The Significance of Circulating Tumor Cells in Patients with Hepatocellular Carcinoma: Real-Time Monitoring and Moving Targets for Cancer Therapy

Chen, F., Zhong, Z., Tan, H. Y., Wang, N. & Feng, Y., Jul 2020, In: Cancers. 12, 7, 23 p., 1734.

Research output: Contribution to journal › Review article › peer-review

Open Access

18 Citations (Scopus)

Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer

Chen, F., Zhong, Z., Tan, H. Y., Guo, W., Zhang, C., Tan, C. W., Li, S., Wang, N. & Feng, Y., 18 Mar 2020, In: Frontiers in Pharmacology. 11, 13 p., 293.

Research output: Contribution to journal › Review article › peer-review

Open Access

19 Citations (Scopus)

2019

Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network

Hong, M., Shi, H., Wang, N., Tan, H. Y., Wang, Q. & Feng, Y., 26 Jun 2019, In: Frontiers in Pharmacology. 10, 17 p., 696.

Research output: Contribution to journal › Review article › peer-review

Open Access

32 Citations (Scopus)

microRNA-23a in Human Cancer: Its Roles, Mechanisms and Therapeutic Relevance

Wang, N., Tan, H. Y., Feng, Y. G., Zhang, C., Chen, F. & Feng, Y., Jan 2019, In: Cancers. 11, 1, 22 p., 7.

Research output: Contribution to journal › Review article › peer-review

Open Access

69 Citations (Scopus)

Polyphenols of Chinese skullcap roots: From chemical profiles to anticancer effects

Wang, L., Zhang, D., Wang, N., Li, S., Tan, H.-Y. & Feng, Y., 15 Aug 2019, In: RSC Advances. 9, 44, p. 25518-25532 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Citations (Scopus)

Recent insights into the role of immune cells in alcoholic liver disease

Li, S., Tan, H.-Y., Wang, N., Feng, Y., Wang, X. & Feng, Y., Jun 2019, In: Frontiers in Immunology. 10, 15 p., 1328.

Research output: Contribution to journal › Review article › peer-review

Open Access

58 Citations (Scopus)

The functional roles of exosomes-derived long non-coding RNA in human cancer

Chen, F., Wang, N., Tan, H. Y., Guo, W., Zhang, C. & Feng, Y., 4 May 2019, In: Cancer Biology and Therapy. 20, 5, p. 583-592 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

43 Citations (Scopus)

Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment

Qu, Y., Dou, B., Tan, H., Feng, Y., Wang, N. & Wang, D., 30 Mar 2019, In: Molecular Cancer. 18, 16 p., 69.

Research output: Contribution to journal › Review article › peer-review

Open Access

79 Citations (Scopus)

2018

Deciphering hepatocellular carcinoma through metabolomics: from biomarker discovery to therapy evaluation

Guo, W., Tan, H. Y., Wang, N., Wang, X. & Feng, Y., 11 Apr 2018, In: Cancer Management and Research. 10, p. 715-734 20 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

40 Citations (Scopus)

Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study

Zhang, C., Wang, N., Xu, Y., Tan, H. Y., Li, S. & Feng, Y., Sept 2018, In: International Journal of Molecular Sciences. 19, 9, 29 p., 2745.

Research output: Contribution to journal › Review article › peer-review

Open Access

66 Citations (Scopus)

Multi-Component Herbal Products in the Prevention and Treatment of Chemotherapy-Associated Toxicity and Side Effects: A Review on Experimental and Clinical Evidences

Fu, B., Wang, N., Tan, H. Y., Li, S., Cheung, F. & Feng, Y., 29 Nov 2018, In: Frontiers in Pharmacology. 9, 15 p., 1394.

Research output: Contribution to journal › Review article › peer-review

Open Access

109 Citations (Scopus)

Targeting tumour microenvironment by tyrosine kinase inhibitor

Tan, H. Y., Wang, N., Lam, W., Guo, W., Feng, Y. & Cheng, Y. C., 19 Feb 2018, In: Molecular Cancer. 17, 15 p., 43.

Research output: Contribution to journal › Review article › peer-review

Open Access

78 Citations (Scopus)

Targeting VEGF/VEGFRs Pathway in the Antiangiogenic Treatment of Human Cancers by Traditional Chinese Medicine

Zhang, C., Wang, N., Tan, H. Y., Guo, W., Li, S. & Feng, Y., Sept 2018, In: Integrative Cancer Therapies. 17, 3, p. 582-601 20 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

28 Citations (Scopus)

The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases

Li, S., Tan, H. Y., Wang, N., Cheung, F., Hong, M. & Feng, Y., 4 Feb 2018, In: Oxidative Medicine and Cellular Longevity. 2018, 26 p., 8394818.

Research output: Contribution to journal › Review article › peer-review

Open Access

144 Citations (Scopus)

2017

Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant

Wang, N., Tan, H. Y., Li, S., Xu, Y., Guo, W. & Feng, Y., 26 Dec 2017, In: Oxidative Medicine and Cellular Longevity. 2017, 14 p., 7478523.

Research output: Contribution to journal › Review article › peer-review

Open Access

166 Citations (Scopus)

Targeting histone methylation for colorectal cancer

Huang, T., Lin, C., Zhong, L., Zhao, L., Zhang, G., Lyu, A., Wu, J. & Bian, Z., 1 Jan 2017, In: Therapeutic Advances in Gastroenterology. 10, 1, p. 114-131 18 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

41 Citations (Scopus)

2016

Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds

Hong, M., Tan, H. Y., Li, S., Cheung, F., Wang, N., Nagamatsu, T. & Feng, Y., 7 Jun 2016, In: International Journal of Molecular Sciences. 17, 6, 23 p., 893.

Research output: Contribution to journal › Review article › peer-review

Open Access

37 Citations (Scopus)

Chinese herbal medicine for constipation: Zheng-based associations among herbs, formulae, proprietary medicines, and herb-drug interactions

Zhong, L., Zheng, G., Ge, L., Lin, C. Y., Huang, T., Zhao, L., Lu, C., Lyu, A. & Bian, Z., 23 Jun 2016, In: Chinese Medicine. 11, 1, 28.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

30 Citations (Scopus)

135 Downloads (Pure)

Hepatoprotective Effects of Chinese Medicinal Herbs: A Focus on Anti-Inflammatory and Anti-Oxidative Activities

Lam, P., Cheung, F., Tan, H. Y., Wang, N., Yuen, M. F. & Feng, Y., 29 Mar 2016, In: International Journal of Molecular Sciences. 17, 4, 37 p., 465.

Research output: Contribution to journal › Review article › peer-review

Open Access

120 Citations (Scopus)

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

Li, S., Hong, M., Tan, H. Y., Wang, N. & Feng, Y., 14 Dec 2016, In: Oxidative Medicine and Cellular Longevity. 2016, 22 p., 4234061.

Research output: Contribution to journal › Review article › peer-review

Open Access

280 Citations (Scopus)

Preclinical Models for Investigation of Herbal Medicines in Liver Diseases: Update and Perspective

Tan, H. Y., San-Marina, S., Wang, N., Hong, M., Li, S., Li, L., Cheung, F., Wen, X. Y. & Feng, Y., 28 Jan 2016, In: Evidence-based Complementary and Alternative Medicine. 2016, 27 p., 4750163.

Research output: Contribution to journal › Review article › peer-review

Open Access

14 Citations (Scopus)

Substitutes for Bear Bile for the Treatment of Liver Diseases: Research Progress and Future Perspective

Li, S., Tan, H. Y., Wang, N., Hong, M., Li, L., Cheung, F. & Feng, Y., 21 Mar 2016, In: Evidence-based Complementary and Alternative Medicine. 2016, 11 p., 4305074.

Research output: Contribution to journal › Review article › peer-review

Open Access

49 Citations (Scopus)

The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases

Tan, H. Y., Wang, N., Li, S., Hong, M., Wang, X. & Feng, Y., 6 Apr 2016, In: Oxidative Medicine and Cellular Longevity. 2016, 17 p., 2795090.

Research output: Contribution to journal › Review article › peer-review

Open Access

452 Citations (Scopus)

2015

An insight into anti-inflammatory effects of fungal beta-glucans

Du, B., Lin, C., BIAN, Z. & Xu, B., 1 Jan 2015, In: Trends in Food Science and Technology. 41, 1, p. 49-59 11 p.

Research output: Contribution to journal › Review article › peer-review

159 Citations (Scopus)

Berberine and Coptidis Rhizoma as potential anticancer agents: Recent updates and future perspectives

Wang, N., Tan, H. Y., Li, L., Yuen, M. F. & Feng, Y., 24 Dec 2015, In: Journal of Ethnopharmacology. 176, p. 35-48 14 p.

Research output: Contribution to journal › Review article › peer-review

129 Citations (Scopus)

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

Hong, M., Li, S., Tan, H. Y., Wang, N., Tsao, S.-W. & Feng, Y., 2 Dec 2015, In: International Journal of Molecular Sciences. 16, 12, p. 28705-28745 41 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

131 Citations (Scopus)

MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy

Hong, M., Wang, N., Tan, H. Y., Tsao, S. W. & Feng, Y., 24 Aug 2015, In: Cancers. 7, 3, p. 1643-1657 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

68 Citations (Scopus)

The Role of Oxidative Stress and Antioxidants in Liver Diseases

Li, S., Tan, H.-Y., Wang, N., Zhang, Z.-J., Lao, L., Wong, C.-W. & Feng, Y., 2 Nov 2015, In: International Journal of Molecular Sciences. 16, 11, p. 26087-26124 38 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1278 Citations (Scopus)

2014

Chinese Medicines Induce Cell Death: The Molecular and Cellular Mechanisms for Cancer Therapy

Wang, X., Feng, Y., Wang, N., Cheung, F., Tan, H. Y., Zhong, S., Li, C. & Kobayashi, S., 14 Oct 2014, In: BioMed Research International. 2014, 15 p., 530342.

Research output: Contribution to journal › Review article › peer-review

Open Access

42 Citations (Scopus)

Centre for Chinese Herbal Medicine Drug Development Limited

Research Output

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