Press conference on cell entry mechanism of SARS-CoV-2 and therapeutic target for COVID-19



A study led by scientists from Hong Kong Baptist University (HKBU) has identified a protease called MT1-MMP that is a major host factor behind the infectivity of the SARS-CoV-2 virus in the human body, which leads to the infection of COVID-19 and multi-organ failure. By applying a humanised antibody called 3A2 that can inhibit the activity of MT1-MMP, the viral load of infected mice was reduced by almost 90%. The research team also demonstrated that the protease is a potential therapeutic target for COVID-19. The research findings have been published in the internationally renowned scientific journal Nature Communications.

Period20 Mar 2023

Media coverage


Media coverage

  • TitleMedia OutReach
    Degree of recognitionLocal
    Media typeWeb
    Country/TerritoryHong Kong
    PersonsHoi Leong Xavier WONG